Research Area E


Wissenschaftsrat gibt grünes Licht für den auf dem CIPSM basierenden Forschungsbau – chemische Epigenetik (ICEM)

Biocatalytic Total Synthesis of Ikarugamycin


Students of the Ernst Mach Gymnasium came to CIPSM.

Proteomics reveals a new DNA repair factor involved in DNA damage signaling

2′-(R)-Fluorinated mC, hmC, fC and caC triphosphates are substrates for DNA polymerases and TET-enzymes

Synthesis of ramariolide natural products and discovery of their targets in mycobacteria

SCAI promotes DNA double-strand break repair in distinct chromosomal contexts

Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells

Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β

Insights into ClpXP proteolysis: Heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes

Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response

Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs

Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

Photocontrol of Polar Aromatic Interactions by a Bis-Hemithioindigo Based Helical Receptor

Activation of the ATR kinase by the RPA-binding protein ETAA1

Expression and purification of EPHA2 tyrosine kinase domain for crystallographic and NMR studies

Self-Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity

K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

A bead-based western for high-throughput cellular signal transduction analyses

Comparison of enzymatic properties and small molecule inhibition of γ–glutamyltranspeptidases from pathogenic and commensal bacteria

Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex

PASylated Coversin, a C5-Specific Complement Inhibitor with Extended Pharmacokinetics, Shows Enhanced Anti-Hemolytic Activity in Vitro

Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action

Twisted Hemithioindigo Photoswitches: Solvent Polarity Determines the Type of Light-Induced Rotations

Fusion of an alcohol dehydrogenase with an aminotransferase using a PAS linker to improve coupled enzymatic alcohol-to-amine conversion

5-Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites

Synthesis of (R)-Configured 2′-Fluorinated mC, hmC, fC, and caC Phosphoramidites and Oligonucleotides

Tumour hypoxia causes DNA hypermethylation by reducing TET activity

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1

DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy

Anticalins directed against vascular endothelial growth factor receptor 3 (VEGFR-3) with picomolar affinities show potential for medical therapy and in vivo imaging

Structural Basis for Bulky-Adduct DNA-Lesion Recognition by the Nucleotide Excision Repair Protein Rad14

Tumor uptake of anti-CD20 Fabs depends on tumor perfusion

BiPPred: Combined sequence- and structure-based prediction of peptide binding to the Hsp70 chaperone BiP

Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity

Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation

ANTICALIgN: visualizing, editing and analyzing combined nucleotide and amino acid sequence alignments for combinatorial protein engineering

A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway

MALDI-TOF and nESI Orbitrap MS/MS identify orthogonal parts of the phosphoproteome

High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer β-amyloid peptide

Structural basis for cellulose binding by the type A carbohydrate-binding module 64 of Spirochaeta thermophila

Active DNA demethylation at enhancers during the vertebrate phylotypic period

Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release

Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors

Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores

Molecular mechanisms of xeroderma pigmentosum (XP) proteins

Towards Understanding Male Infertility After Spinal Cord Injury Using Quantitative Proteomics

Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA

Selection and characterization of Anticalins targeting human prostate-specific membrane antigen (PSMA)

Making a Long Journey Short: Alkyne Functionalization of Natural Product Scaffolds

An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression


TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

Season's Greetings and Best Wishes for a Happy New Year 2016 from CIPSM

moCluster: Identifying Joint Patterns Across Multiple Omics Data Sets

Extending Polyketide Structural Diversity by Using Engineered Carboxylase/Reductase Enzymes

UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair

Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity

Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities

CIPSM in ARD & BR alpha television

Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association

Optische Kontrolle der Insulinsekretion mit einem Inkretinschalter

Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lepob/ob Mice

Molecular mechanisms behind the antimicrobial activity of hop iso-α-acids in Lactobacillus brevis

Anticalins directed against the fibronectin extra domain B as diagnostic tracers for glioblastomas

Sunlight-powered kHz rotation of a hemithioindigo-based molecular motor

Optimisation of a system for the co-translational incorporation of a keto amino acid and its application to a tumour-specific Anticalin

Evaluation of Kinase Activity Profiling Using Chemical Proteomics

Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogue

CRISPR-Cas: From the Bacterial Adaptive Immune System to a Versatile Tool for Genome Engineering

Engineering of alanine dehydrogenase from Bacillus subtilis for novel cofactor specificity

Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site

Stability engineering of the Geobacillus stearothermophilus alcohol dehydrogenase and application for the synthesis of a polyamide 12 precursor

Kinetic and Theoretical Studies of Beta-Lactone Reactivity—A Quantitative Scale for Biological Application

Hemithioindigo—an emerging photoswitch

Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)

Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues

Semi-supervised Learning Predicts Approximately One Third of the Alternative Splicing Isoforms as Functional Proteins

Dewar Lesion Formation in Single- and Double-Stranded DNA is Quenched by Neighboring Bases

Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization

Inhibitor-based affinity probes for the investigation of JAK signaling pathways

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma

89Zr-Labeled Versus 124I-Labeled αHER2 Fab with Optimized Plasma Half-Life for High-Contrast Tumor Imaging In Vivo

A Scalable Approach for Protein False Discovery Rate Estimation in Large Proteomic Data Sets

Chemical Proteomics Uncovers EPHA2 as a Mechanism of Acquired Resistance to Small Molecule EGFR Kinase Inhibition

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links
TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

Crystal structure of the human odorant binding protein, OBPIIa

Orchestrating the Biosynthesis of an Unnatural Pyrrolysine Amino Acid for Its Direct Incorporation into Proteins Inside Living Cells

PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy

A Mass Spectrometry Platform for a Streamlined Investigation of Proteasome Integrity, Posttranslational Modifications, and Inhibitor Binding

The Menagerie of Human Lipocalins: A Natural Protein Scaffold for Molecular Recognition of Physiological Compounds

CIPSM-Mitgliedsversammlung 2015
Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin

AAA+ chaperones and acyldepsipeptides activate the ​ClpP protease via conformational control

Arginine-rhamnosylation as new strategy to activate translation elongation factor P

Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling

Structure and Mechanism of the Caseinolytic Protease ClpP1/2 Heterocomplex from Listeria monocytogenes

Synthesis and biological evaluation of a novel MUC1 glycopeptide conjugate vaccine candidate comprising a 4’-deoxy-4’-fluoro-Thomsen–Friedenreich epitope

Photocontrolled chignolin-derived β-hairpin peptidomimetics

Homology-driven assembly of NOn-redundant protEin sequence sets (NOmESS) for mass spectrometry

The dimeric crystal structure of the human fertility lipocalin glycodelin reveals a protein scaffold for the presentation of complex glycans


Design and Characterization of a Modular Membrane Protein Anchor to Functionalize the Moss Physcomitrella patens with Extracellular Catalytic and/or Binding Activities

Season's Greetings and Best Wishes for a Happy New Year from CIPSM
Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures
Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action

DNA methylation and differential gene regulation in photoreceptor cell death

Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli

Disruption of the PRKCD–FBXO25–HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis

High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation

Structure of a Putative Fluorinated Natural Product from Streptomyces sp. TC1

Comprehensive and Reproducible Phosphopeptide Enrichment Using Iron Immobilized Metal Ion Affinity Chromatography (Fe-IMAC) Columns

CIPSM-Business: CIPSM closes licence deal with BASF
Making Fast Photoswitches Faster—Using Hammett Analysis to Understand the Limit of Donor–Acceptor Approaches for Faster Hemithioindigo Photoswitches
Watson–Crick Base Pairing Controls Excited-State Decay in Natural DNA
PAS-cal: A repetitive peptide sequence calibration standard for MALDI mass spectrometry
Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site
Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase
Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition
Enhanced in Vivo Efficacy of a Type I Interferon Superagonist with Extended Plasma Half-life in a Mouse Model of Multiple Sclerosis
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice
Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics
Ribose-Protonated DNA Base Excision Repair: A Combined Theoretical and Experimental Study
Making the Bend: DNA Tertiary Structure and Protein-DNA Interactions
The Biocatalytic Repertoire of Natural Biaryl Formation
Exzellenzcluster trifft 8. Klasse am Gymnasium
Characterization of acute myeloid leukemia based on levels of global hydroxymethylation

Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach

A Fab fragment directed against the neural cell adhesion molecule L1 enhances functional recovery after injury of the adult mouse spinal cord
A multivariate approach to the integration of multi-omics datasets
PAS-cal: a Generic Recombinant Peptide Calibration Standard for Mass Spectrometry
Mass-spectrometry-based draft of the human proteome
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
Derivatization of Antibody Fab Fragments: A Designer Enzyme for Native Protein Modification
Structural Basis for the Site-Specific Incorporation of Lysine Derivatives into Proteins
Probing SH2-domains using Inhibitor Affinity Purification (IAP)
New Affinity Probe Targeting VEGF Receptors for Kinase Inhibitor Selectivity Profiling by Chemical Proteomics
Charge separation and charge delocalization identified in long-living states of photoexcited DNA
A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage
Fingerprinting DNA Oxidation Processes: IR Characterization of the 5-Methyl-2′-Deoxycytidine Radical Cation
A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice
CIPSM Awards 2014
Targeted Mutagenesis Results in an Activation of DNA Methyltransferase 1 and Confirms an Autoinhibitory Role of its RFTS Domain
Biochemical Analysis of Recombinant AlkJ from Pseudomonas putida Reveals a Membrane-Associated, Flavin Adenine Dinucleotide- Dependent Dehydrogenase Suitable for the Biosynthetic Production of Aliphatic Aldehydes
Structure-guided engineering of Anticalins with improved binding behavior and biochemical characteristics for application in radio-immuno imaging and/or therapy
Formation and Direct Repair of UV-induced Dimeric DNA Pyrimidine Lesions
Synthesis of functionalized α-trifluoroethyl amine scaffolds via Grignard addition to N-aryl hemiaminal ethers
Anticalins: Exploiting a non-Ig scaffold with hypervariable loops for the engineering of binding proteins
A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors
Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences
Synthese eines DNA-Promotorsegments mit allen vier epigenetischen Nukleosiden: 5-Methyl-, 5-Hydroxymethyl-, 5-Formyl- und 5-Carboxy-2′-Desoxycytidin


Frohe Weinhachten und ein gutes neues Jahr!
Sortase-catalyzed in vitro functionalization of a HER2-specific recombinant Fab for tumor targeting of the plant cytotoxin gelonin
A Photoswitchable Neurotransmitter Analogue Bound to Its Receptor
α-Methylene-γ-butyrolactones attenuate Staphylococcus aureus virulence by inhibition of transcriptional regulation
Structural Insights into Incorporation of Norbornene Amino Acids for Click Modification of Proteins
β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues
Copper-Assisted Click Reactions for Activity-Based Proteomics: Fine-Tuned Ligands and Refined Conditions Extend the Scope of Application
Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition
Comprehensive Identification of Proteins from MALDI Imaging
Norbornenes in Inverse Electron-Demand Diels–Alder Reactions
CIPSM on the run
CIPSM Scientific Oktoberfest 2013
Amythiamicin D and Related Thiopeptides as Inhibitors of the Bacterial Elongation Factor EF-Tu: Modification of the Amino Acid at Carbon Atom C2 of Ring C Dramatically Influences Activity
Deamination, Oxidation, and C−C Bond Cleavage Reactivity of 5‑Hydroxymethylcytosine, 5‑Formylcytosine, and 5‑Carboxycytosine
DMSO enhances electrospray response, boosting sensitivity of proteomic experiments
A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization
Global Proteome Analysis of the NCI-60 Cell Line Panel
Characterization of a high field Orbitrap mass spectrometer for proteome analysis
Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad
The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity
Crystallographic Analysis and Structure-Guided Engineering of NADPH-Dependent Ralstonia sp. Alcohol Dehydrogenase Toward NADH Cosubstrate Specificity
The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity
Nature calls CIPSM a prime example for a working conduit between university, non-university and R&D business in Germany. „CIPSM features regularly in the Nature Publicing Index“
Characterization of a Chemical Affinity Probe Targeting Akt Kinases
Measuring and Managing Ratio Compression for Accurate iTRAQ/ TMT Quantification
PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins
Total Synthesis of the Hypermodified tRNA Nucleoside Epoxyqueuosine
Unexpected non-Hoogsteen–based mutagenicity mechanism of FaPy-DNA lesions
A large synthetic peptide and phosphopeptide reference library for mass spectrometry–based proteomics
MScDB: A Mass Spectrometry-centric Protein Sequence Database for Proteomics
Cleavable trifunctional biotin reagents for protein labelling, capture and release
Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone
Proteomic workflow for analysis of archival formalin-fixed and paraffin-embedded clinical samples to a depth of 10 000 proteins
Comparing Immobilized Kinase Inhibitors and Covalent ATP Probes for Proteomic Profiling of Kinase Expression and Drug Selectivity
The Mechanism of Caseinolytic Protease (ClpP) Inhibition
Combinatorial Design of an Anticalin Directed against the Extra-Domain B for the Specific Targeting of Oncofetal Fibronectin
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Total Synthesis of the Hypermodified RNA Bases Wybutosine and Hydroxywybutosine and Their Quantification Together with Other Modified RNA Bases in Plant Materials
Tuning probe selectivity for chemical proteomics applications
Conformational Selection in Substrate Recognition by Hsp70 Chaperones
Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay
Crystal structure of the ω-aminotransferase from Paracoccus denitrificans and its phylogenetic relationship with other class III amino- transferases that have biotechnological potential
Proteome Wide Purification and Identification of O-GlcNAc-Modified Proteins Using Click Chemistry and Mass Spectrometry
Synthesis of 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine-triphosphates and Their Incorporation into Oligonucleotides by Polymerase Chain Reaction
Total Syntheses and Biological Evaluation of 3-O-Methylfunicone and Its Derivatives Prepared by TMPZnCl·LiCl-Mediated Halogenation and Carbonylative Stille Cross-Coupling
Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system


SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification
Alternative bacterial two-component small heat shock protein systems
The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair
Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 30-splice site recognition
Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system
Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples*
Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency
A Simple and Effective Cleavable Linker for Chemical Proteomics Applications Yinliang Yang,
Label-Free Microscale Thermophoresis Discriminates Sites and Affinity of Protein–Ligand Binding
Deactivation of the E. coli pH Stress Sensor CadC by Cadaverine
Azo-Propofols: Photochromic Potentiators of GABAA Receptors
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
Evolution of a Synthetic Strategy for the Variecolortide
A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity
Nature mentions CIPSMs’ graduate educational program in it’s highlight article about the German Excellence Initiative
Homotypic Interaction and Amino Acid Distribution of Unilaterally Conserved Transmembrane Helices
Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers
In vitro Percutaneous Absorption of 14C-Labeled β-Lactone Promises Topical Delivery of New Bacterial Virulence Inhibitors
Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme
Structure and Function of Noncanonical Nucleobases
CIPSM selected as Cluster of Excellence once more... YEAH!
Dynamics of ultraviolet-induced DNA lesions: Dewar formation guided by pre-tension induced by the backbone
Sequence-dependent backbone dynamics of a viral fusogen transmembrane helix
Synthetic approaches toward sesterterpenoids
Discovery of the HSP90 regulated proteome by CIPSM scientists featured on the cover of Mol Cell Proteomics
A Unified Approach to trans-Hydrindane Sesterterpenoids
Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope Tracing
Stereoselective Total Syntheses of Herbicidin C and Aureonuclemycin through Late-Stage Glycosylation
ONIOM approach for non-adiabatic on-the-fly molecular dynamics demonstrated for the backbone controlled Dewar valence isomerization
Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy
A Total Synthesis Prompts the Structure Revision of Haouamine B
A Genetically Encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-Free Click Reaction
A Photochromic Agonist of AMPA Receptors
Electrophilic natural products and their biological targets
Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage
H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA
Total Synthesis of Exiguamines A and B Inspired by Catecholamine Chemistry
The 19S Cap Puzzle: A New Jigsaw Piece
Radiolabelled RGD peptides for imaging and therapy
Rapid optical control of nociception with an ion-channel photoswitch
Rapid optical control of nociception with an ion-channel photoswitch
Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
Discovery and Mutagenicity of a Guanidinoformimine Lesion as a new Intermediate of the Oxidative Deoxyguanosine Degradation Pathway
Consecutive Proteolytic Digestion in an Enzyme Reactor Increases Depth of Proteomic and Phosphoproteomic Analysis
Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis
Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis
Exploiting nature’s rich source of proteasome inhibitors as starting points in drug development
An Approach to Aminonaphthoquinone Ansamycins Using a Modified Danishefsky Diene
Insights into the Structural Network Responsible for Oligomerization and Activity of the Bacterial Virulence Regulator Caseinolytic Protease P (Clpp)
Development and characterization of improved β-lactone-based anti-virulence drugs targeting Clp
Low values of 5-hydroxymethylcytosine (5hmC), the ‘‘sixth base,’’ are associated with anaplasia in human brain tumors
Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
Mechanism of UV-Induced Formation of Dewar Lesions in DNA
The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
Beta-Lactams and Beta-lactones as activity-based probes in chemical biology
Tetraalkylcuprates(III): Formation, Association, and Intrinsic Reactivity


Optochemical Genetics
Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxylcytosine
Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes
Deep proteome and transcriptome mapping of a human cancer cell line
The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling
Systems-Based Analysis of Modified tRNA Bases
Pictures of the Scientific Oktoberfest 2011
Scientific Oktoberfest: CIPSM-Fest of Chemical Biology 2011
Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4
Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair
The Discovery of 5-Formylcytosine in Embryonic Stem Cell DNA
PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand
5-Hydroxymethylcytosine, the Sixth Base of the Genome
Unraveling the Protein Targets of Vancomycin in Living S. aureus and E. faecalis Cells
Evaluation of α-Pyrones and Pyrimidones as Photoaffinity Probes for Affinity-Based Protein Profiling
Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain
An efficient synthesis of loline alkaloids
Tuning Photochromic Ion Channel Blockers
Identification and characterization of a novel ubiquitous nucleolar protein ‘NARR’ encoded by a gene overlapping the rab34 oncogene
A Conformational Switch Underlies ClpP Protease Function
High Recovery FASP Applied to the Proteomic Analysis of Microdissected Formalin Fixed Paraffin Embedded Cancer Tissues Retrieves Known Colon Cancer Markers
A Novel Two-Stage Tandem Mass Spectrometry Approach and Scoring Scheme for the Identification of O-GlcNAc Modified Peptides
Discovery and Synthesis of New UV-Induced Intrastrand C(4−8)G and G(8−4)C Photolesions
Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases
Structure and dynamics of the lipid modifications of a transmembrane Alpha-helical peptide determined by 2H solid-state NMR spectroscopy
Biosynthesis of a Fluorescent Protein with Extreme Pseudo-Stokes Shift by Introducing a Genetically Encoded Non-Natural Amino Acid outside the Fluorophore
Synthetic Studies toward A-74528
The ribosomaltunnelasafunctionalenvironmentfornascent polypeptide foldingandtranslationalstalling
Concise Total Syntheses of Variecolortides A and B through an Unusual Hetero-Diels–Alder Reaction
Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family
Elucidation of the a-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition
New Insights into the Signaling Mechanism of the pH-responsive, Membrane-integrated Transcriptional Activator CadC of Escherichia coli
The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity


Protein Reactivity of Natural Product-Derived γ-Butyrolactones
Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
Biosynthesis of Isoprenoids: Crystal Structure of the [4Fe–4S] Cluster Protein IspG
Elucidation of the a-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition
Comparison of ultrafiltration units for proteomic and N-glycoproteomic analysis by the filter-aided sample preparation method
Toward the Total Synthesis of Maoecrystal V: Establishment of Contiguous Quaternary Stereocenters
Mechanism of replication blocking and bypass of Y-family polymerase Eta by bulky acetylaminofluorene DNA adducts
Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner
Confident phosphorylation site localization using the Mascot Delta Score
Confident phosphorylation site localization using the Mascot Delta Score
Residue-Specific Side-Chain Packing Determines the Backbone Dynamics of Transmembrane Model Helices
The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds
Reductive Dehydroxylation of Allyl Alcohols by IspH Protein
Pharmacology of ionotropic glutamate receptors: A structural perspective
CIPSM spin-off AVIRU gets funding from the German Parliament
Synthesis and Antiplasmodial Activity of Highly Active Reverse Analogues of the Antimalarial Drug Candidate Fosmidomycin
20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A
Total synthesis of newbouldine via reductive N - N bond formation
Biomimetic Synthesis of (−)-Pycnanthuquinone C through the Diels–Alder Reaction of a Vinyl Quinone
Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain
Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors
Proteomics: a pragmatic perspective
CIPSM spin-off XL-protein GmbH awarded with the 2010 Science4Life Venture Cup
Chemical Probes for Labeling of the Bacterial Glucosaminidase NagZ via the Huisgen Cycloaddition
The 26S proteasome: assembly and function of a destructive machine
CIPSM at the elementary school
Proteome, Phosphoproteome, and N-Glycoproteome Are Quantitatively Preserved in Formalin-Fixed Paraffin-Embedded Tissue and Analyzable by High-Resolution Mass Spectrometry
Exzellenzinitiative für die Grundschule - CIPSM unterrichtet Grundschüler
Thomas Carell was honored with the Cross of Merit on ribbon of the Federal Republic of Germany
Showdomycin as a Versatile Chemical Tool for the Detection of Pathogenesis-Associated Enzymes in Bacteria
Brain Phosphoproteome Obtained by a FASP-Based Method Reveals Plasma Membrane Protein Topology
Oxidation State, Aggregation, and Heterolytic Dissociation of Allyl Indium Reagents
Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies
Crystal Structure of a Cisplatin-(1,3-GTG) Cross-Link within DNA Polymerase eta
A Highly Charged Ag6 4+ Core in a DNA-Encapsulated Silver Nanocluster
DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions
Probing the reaction mechanism of IspH protein by x-ray structure analysis
Structural features of fusogenic model transmembrane domains that differentially regulate inner and outer leaflet mixing in membrane fusion


Ionic interactions promote transmembrane helix-helix association depending on sequence context
Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice
Synthesis of Threefold Glycosylated Proteins using Click Chemistry and Genetically Encoded Unnatural Amino Acids
Light Commands Ion Channel
Microsolvated and Chelated Butylzinc Cations: Formation, Relative Stability, and Unimolecular Gas-Phase Chemistry
Combination of FASP and StageTip-Based Fractionation Allows In-Depth Analysis of the Hippocampal Membrane Proteome
CIPSM PI and board member Arne Skerra and his new spin-off company XL-protein GmbH prolong the plasma half-life of biopharmaceutical substances
DynaDock: A new molecular dynamics-based algorithm for protein-peptide docking including receptor flexibility
A Photolabile Linker for the Mild and Selective Cleavage of Enriched Biomolecules from Solid Support
A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity
Parallel Isotope-Based Quantification of Modified tRNA Nucleosides
Syringolin A Selectively Labels the 20S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines
Once Overlooked, Now Made Visible: ATL Proteins and DNA Repair
Crystal Structure of the T(6-4)C Lesion in Complex with a (6-4) DNA Photolyase and Repair of UV-Induced (6-4) and Dewar Photolesions
Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights for Fine Tuning Proteasome Inhibition
beta-Lactones Decrease the Intracellular Virulence of Listeria monocytogenes in
Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of ß-secretase (BACE1)
A new ground state single electron donor for excess electron transfer studies in DNA
Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction
NMR Structure and Dynamics of the Engineered Fluorescein-Binding Lipocalin FluA Reveal Rigidification of β-Barrel and Variable Loops upon Enthalpy-Driven Ligand Binding
Alpenforum 2009
Structural biology of DNA photolyases and cryptochromes
CIPSM-Harvard Young Scientists' Forum (YSF)
Cinnamic aldehyde derived probes for the active site labelling of pathogenesis associated enzymes
Interaction and conformational dynamics of membrane-spanning protein helices
Stabilization of conformationally dynamic helices by covalently attached acyl chains
Bilder von der CIPSM-Festveranstaltung im Deutschen Museum am 4. Mai 2009
An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies
CIPSM-Festveranstaltung im Deutschen Museum am 4. Mai 2009
The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes
Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein
Natural product inhibitors of protein–protein interactions mediated by Src-family SH2 domains
Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition
Universal sample preparation method for proteome analysis
Sequence-specific conformational dynamics of model transmembrane domains determines their membrane fusogenic function
beta-Lactam Probes As Selective Chemical-Proteomic Tools for the Identification and Functional Characterization of Resistance Associated Enzymes in MRSA
Copper-Free “Click” Modification of DNA via Nitrile Oxide-Norbornene 1,3-Dipolar Cycloaddition
Protein Iodination by Click Chemistry
CIPSM Movie online stream
Allosteric Switches: Remote Controls for Proteins
Unraveling the Secrets of Protein-Metabolite Interactions
Imaging of integrin alpha-v-beta-3 expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography
High-Affinity Recognition of Lanthanide(III) Chelate Complexes by a Reprogrammed Human Lipocalin 2
Phosphorothioation of Oligonucleotides Strongly Influences the Inhibition of Bacterial (M.HhaI) and Human(Dnmt1) DNA Methyltransferases
Structurally Refined b-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors
A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis
Crystal structure analysis of DNA lesion repair and tolerance mechanisms
Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs
Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
Formation of Organozincate Anions in LiCl-Mediated Zinc Insertion Reactions
Controlled Nucleation of DNA Metallization


The persisting challenge of selective and specific proteasome inhibition
Aggregation and Reactivity of Organozincate Anions Probed by Electrospray Mass Spectrometry
Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome
Identification of potential substrate proteins for the periplasmic Escherichia coli chaperone Skp
CIPSM ist Ausgewählter Ort im Land der Ideen
A Human snoRNA with MicroRNA-Like Functions
Novel Diazirine-Containing DNA Photoaffinity Probes for the Investigation of DNA-Protein-Interactions
Evidence for Insertional RNA Editing in Humans
5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Complex patterns of histidine, hydroxylated amino acids and the GxxxG motif mediate high-affinity transmembrane domain interactions
Crystal Structure and Mechanism of a DNA (6-4) Photolyase
Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment
Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides
Azatryptophans endow proteins with intrinsic blue fluorescence
Structural Analysis of Spiro b-Lactone Proteasome Inhibitors
CIPSM-Researchers Stephan Sieber and Thomas Böttcher win the Innovation award 2008 of the BioRegions in Germany
Beta-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors of Staphylococcus aureus
Postsynthetic DNA Modification through the Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction
The 1.8-Å Crystal Structure of α1-Acid Glycoprotein (Orosomucoid) Solved by UV RIP Reveals the Broad Drug-Binding Activity of This Human Plasma Lipocalin
Beta-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence
Hier geht was!
Intracellular uptake and inhibitory activity of aromatic fluorinated amino acids in human breast cancer cells
Convenient syntheses of homopropargylglycine
Inhibition of transcription factors with small organic molecules
Inhibition of transcription factors with small organic molecules
Exploiting Cross-Amyloid Interactions To Inhibit Insulin Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic
Biomimetic synthesis of the IDO inhibitors exiguamine A and B
Sequence-Specific Conformational Flexibility of SNARE Transmembrane Helices Probed by Hydrogen/Deuterium Exchange
Synthesis and properties of DNA containing a spore photoproduct analog
Fpg (MutM) recognizes bulky N7-substituted-FapydG lesion using a novel and unproductive binding mode
Synthesis of a Stabilized Version of the Imidazolone DNA Lesion
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
Docking of tryptophan analogs to trytophanyl-tRNA synthetase: implications for non-canonical amino acid incorporations
A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase
Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions
Signal Transducers and Activators of Transcription as Targets for Small Organic Molecules
Temperature and pressure dependence of protein stability: The engineered fluorescein-binding lipocalin FluA shows an elliptic phase diagram
A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
beta-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes
Efficient N-Terminal Glycoconjugation of Proteins by the N-End Rule
Synthetic Biology of Proteins: Tuning GFPs Folding and Stability with Fluoroproline
Bayer Schering Pharma and CIPSM sign a strategic partnership
Discovery of Chromone-Based Inhibitors of the Transcription Factor STAT5
Synthesis of DNA Dumbbell Based Inhibitors for the Human DNA Methyltransferase Dnmt1
A high-throughput assay for signal transducer and activator of transcription 5b based on fluorescence polarization
Requirement for Small Side Chain Residues within the GxGD-Motif of Presenilin for gamma-Secretase Substrate Cleavage
Dissecting the Differences between the a and b Anomers of the Oxidative DNA Lesion FaPydG
The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site


Selective Detection of 5-Methylcytosine Sites in DNA
Secondary structure and distribution of fusogenic LV-peptides in lipid membranes
CIPSM-Speaker Thomas Carell wins 2008 Otto-Bayer-Preis
Nature Spotlight on Germany
Seeing Cisplatin - Discerning how an anticancer drug meddles with replication, transcription
Mechanism of transcriptional stalling at cisplatindamaged DNA
Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase Eta
Structural Insight into the Dual Ligand Specificity and Mode of High Density Lipoprotein Association of Apolipoprotein D
miRNAs Get an Early Start on Translational Silencing
Phenylalanine Promotes Interaction of Transmembrane Domains via GxxxG Motifs
The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins
CPD Damage Recognition by Transcribing RNA Polymerase II
TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry