Natural product inhibitors of protein–protein interactions mediated by Src-family SH2 domains

Bioorganic & Medical Chemistry Letters, 2009, doi:10.1016/j.bmcl.2009.04.083, published on 23.04.2009
Bioorganic & Medical Chemistry Letters, online article
In this Letter, we report the natural products salvianolic acid A, salvianolic acid B, and caftaric acid as inhibitors of the protein–protein interactions mediated by the SH2 domains of the Src-family kinases Src and Lck, two established disease targets. Moreover, we propose a binding mode for the inhibitors based on molecular modeling, which will facilitate chemical optimization efforts of these important lead structures for drug discovery.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry