Research Area E - Publications 2018

Biochemistry, 2018, 57 (11), pp 1814–1820, DOI: 10.1021/acs.biochem.7b01271
Biochemistry, online article

 

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Staphylococcus aureus is a major bacterial pathogen that invades and damages host tissue by the expression of devastating toxins. We here performed a phenotypic screen of 35 molecules that were structurally inspired by previous hydroxyamide-based S. aureus virulence inhibitors compiled from commercial sources or designed and synthesized de novo. One of the most ...

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Wir freuen uns, dass der Bau unseres neuen CIPSM Gebäudes, das Institut für Chemische Epigenetik ICEM nun beginnt.

Damit Sie im Bilde sind und sich darauf einstellen können finden Sie hier die relevanten Eckdaten zur Baustelle Neubau ICEM:
 

1. Baustelleneinrichtung ab ca. 15.09.2017

2. Beginn Erdarbeiten/Spezialtiefbau ab ca. 30.09.2017

3. Beginn ...

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Nature Communications, 9, Article number: 163, doi:10.1038/s41467-017-02639-1
Nature Communications, online article

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The molecules of life were created by a continuous physicochemical process on an early Earth. In this hadean environment, chemical transformations were driven by fluctuations of the naturally given physical parameters established for example by wet–dry cycles. These conditions might have allowed for the formation of (self)-replicating RNA as the fundamental ...

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Angewandte Chemie International Edition, DOI: 10.1002/anie.201708867
Angewandte Chemie International Edition, online article

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Modern proteomics requires reagents for exact quantification of peptides in complex mixtures. Peptide labelling is most typically achieved with isobaric tags that consist of a balancer and a reporter part that separate in the gas phase. An ingenious distribution of stable isotopes provides multiple reagents with identical molecular weight but a different mass of ...

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J. Am. Chem. Soc., 2018, 140 (5), pp 1774–1782, DOI: 10.1021/jacs.7b11212
J. Am. Chem. Soc., online article

 

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Natural products have served as an inspiration to scientists both for their complex three-dimensional architecture and exquisite biological activity. Promysalin is one such Pseudomonad secondary metabolite that exhibits narrow-spectrum antibacterial activity, originally isolated from the rhizosphere. We herein utilize affinity-based protein profiling (AfBPP) to ...

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