Research Area E - Publications 2018

ChemPhotoChem 2018, 2, 1–8, https://doi.org/10.1002/cptc.201700228
ChemPhotoChem, online article

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Substituted indigo derivatives undergo photoisomerization of the central double bond if both nitrogen atoms are functionalized. Indigo itself however does not photoisomerize because of a competing and highly efficient excited‐state proton transfer. In this work, we show that also mono‐arylated indigo undergoes photoisomerization despite still possessing one ...

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Nature Communications, volume 9, Article number: 1456 (2018), doi:10.1038/s41467-018-03912-7
Nature Communications, online article

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Remote control of complex molecular behavior and function is one key problem in modern chemistry. Using light signaling for this purpose has many advantages, however the integration of different photo processes into a wholesome yet complex system is highly challenging. Here we report an alternative approach to increase complexity of light control-simultaneous ...

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J. Am. Chem. Soc., 2018, 140 (15), pp 5311–5318, DOI: 10.1021/jacs.8b02349
J. Am. Chem. Soc., online article

 

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Hemithioindigo-based molecular motors are powered by nondamaging visible light and provide very fast directional rotations at ambient conditions. Their ground state energy profile has been probed in detail, but the crucial excited state processes are completely unknown so far. In addition, very fast processes in the ground state are also still elusive to date and ...

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Phys. Chem. Chem. Phys., 2018,20, 6868-6876, DOI: 10.1039/C8CP00096D
Phys. Chem. Chem. Phys., online article

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Hemithioindigo compounds are attractive two-way molecular photoswitches combining stilbene and thioindigo parts connected by a C–C double bond. In solution, these photoswitches have been well studied. This study presents the investigation of a hemithioindigo derivative in the gas phase. Visible absorption spectra, measured by standard (visPD) and helium-tagging ...

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Biochemistry, 2018, 57 (11), pp 1814–1820, DOI: 10.1021/acs.biochem.7b01271
Biochemistry, online article

 

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Staphylococcus aureus is a major bacterial pathogen that invades and damages host tissue by the expression of devastating toxins. We here performed a phenotypic screen of 35 molecules that were structurally inspired by previous hydroxyamide-based S. aureus virulence inhibitors compiled from commercial sources or designed and synthesized de novo. One of the most ...

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Nature Communications, 9, Article number: 163, doi:10.1038/s41467-017-02639-1
Nature Communications, online article

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The molecules of life were created by a continuous physicochemical process on an early Earth. In this hadean environment, chemical transformations were driven by fluctuations of the naturally given physical parameters established for example by wet–dry cycles. These conditions might have allowed for the formation of (self)-replicating RNA as the fundamental ...

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Angewandte Chemie International Edition, DOI: 10.1002/anie.201708867
Angewandte Chemie International Edition, online article

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Modern proteomics requires reagents for exact quantification of peptides in complex mixtures. Peptide labelling is most typically achieved with isobaric tags that consist of a balancer and a reporter part that separate in the gas phase. An ingenious distribution of stable isotopes provides multiple reagents with identical molecular weight but a different mass of ...

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J. Am. Chem. Soc., 2018, 140 (5), pp 1774–1782, DOI: 10.1021/jacs.7b11212
J. Am. Chem. Soc., online article

 

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Natural products have served as an inspiration to scientists both for their complex three-dimensional architecture and exquisite biological activity. Promysalin is one such Pseudomonad secondary metabolite that exhibits narrow-spectrum antibacterial activity, originally isolated from the rhizosphere. We herein utilize affinity-based protein profiling (AfBPP) to ...

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Nature Structural & Molecular Biology, volume 25,  90–100 (2018), doi:10.1038/s41594-017-0012-6
Nature Structural & Molecular Biology, online article

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BiP is the endoplasmic member of the Hsp70 family. BiP is regulated by several co-chaperones including the nucleotide-exchange factor (NEF) Bap (Sil1 in yeast). Bap is a two-domain protein. The interaction of the Bap C-terminal domain with the BiP ATPase domain is sufficient for its weak NEF activity. However, stimulation of the BiP ATPase activity requires ...

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