Research Area E - Publications 2020

PLoS ONE, 15(2): e0229144, https://doi.org/10.1371/journal.pone.0229144
PLoS ONE, online article

2020_schneider_plosone_550.100x0.jpg

The multi-domain protein UHRF1 is essential for DNA methylation maintenance and binds DNA via a base-flipping mechanism with a preference for hemi-methylated CpG sites. We investigated its binding to hemi- and symmetrically modified DNA containing either 5-methylcytosine (mC), 5-hydroxymethylcytosine (hmC), 5-formylcytosine (fC), or 5-carboxylcytosine (caC). Our ...

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