Research Area F


In vivo deep two-photon imaging of neural circuits with the fluorescent Ca2+ indicator Cal-590


Improved deep two-photon calcium imaging in vivo

Quantifying macromolecular interactions in living cells using FRET two-hybrid assays

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination

The Impact of the ‘Austrian’ Mutation of the Amyloid Precursor Protein Transmembrane Helix is Communicated to the Hinge Region

Super-resolution microscopy writ large

AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments

Photoswitchable diacylglycerols enable optical control of protein kinase C

Imaging of neuronal mitochondria in situ

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

Impairments of neural circuit function in Alzheimer's disease

Stem Cell–Derived Photoreceptor Transplants Differentially Integrate Into Mouse Models of Cone-Rod Dystrophy

Cav1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice

Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology

Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response

In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors

A family of photoswitchable NMDA receptors

Entrapment of Water at the Transmembrane Helix–Helix Interface of Quiescin Sulfhydryl Oxidase 2

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors

Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization

Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia


Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO)

Engulfment pathways promote programmed cell death by enhancing the unequal segregation of apoptotic potential

Comprehensive multilevel in vivo and in vitro analysis of heart rate fluctuations in mice by ECG telemetry and electrophysiology

Synthetic approaches towards alkaloids bearing α-tertiary amines

Optische Kontrolle der Insulinsekretion mit einem Inkretinschalter

Restoring Light Sensitivity in Blind Retinae Using a Photochromic AMPA Receptor Agonist

Rescue of long-range circuit dysfunction in Alzheimer's disease models

The loss of LRPPRC function induces the mitochondrial unfolded protein response

Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ‑Secretase

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif

An eight-step synthesis of epicolactone reveals its biosynthetic origin

Optical control of NMDA receptors with a diffusible photoswitch

Deep two-photon brain imaging with a red-shifted fluorometric Ca2+ indicator

Role of GxxxG Motifs in Transmembrane Domain Interactions

Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotyp

Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death

Azobenzene-based inhibitors of human carbonic anhydrase II

Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues

TRPC3‐dependent synaptic transmission in central mammalian neurons

Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice

cGMP/PKG Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of CNG Channel-Deficient Mice

Photoswitchable fatty acids enable optical control of TRPV1
αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell–related features

Understanding intramembrane proteolysis: from protein dynamics to reaction kinetics

Biomimetic Total Synthesis of Santalin Y
Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells
TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression

Vitreal delivery of AAV vectored Cnga3 restores cone function in CNGA3−/−/Nrl−/− mice, an all-cone model of CNGA3 achromatopsia

Neuronal hyperactivity – A key defect in Alzheimer's disease?
Neuroscience’s answer to the Nobel Prize - The Brain Prize 2015 - goes in part to CIPSM researcher Arthur Konnerth for the invention, development and application of the revolutionary technique two-photon microscopy
AzoCholine Enables Optical Control of Alpha 7 Nicotinic Acetylcholine Receptors in Neural Networks
Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment
A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function
Calculated Nuclear Magnetic Resonance Spectra of Polytwistane and Related Hydrocarbon Nanorods
Redox imaging using genetically encoded redox indicators in zebrafish and mice

Retinal gene delivery by adeno-associated virus (AAV) vectors: Strategies and applications

Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice

Dendritic function in vivo


Synthetic Studies toward Polytwistane Hydrocarbon Nanorods

A recoverable state of axon injury persists for hours after spinal cord contusion in vivo

DNA methylation and differential gene regulation in photoreceptor cell death

In Vivo Imaging of Mitochondria in Intact Zebrafish Larvae

Differential Regulation of Germline Apoptosis in Response to Meiotic Checkpoint Activation

Rods in daylight act as relay cells for cone-driven horizontal cell–mediated surround inhibition
An assay to image neuronal microtubule dynamics in mice
Total Synthesis of the Proposed Structure of Trichodermatide A
High susceptibility to fatty liver disease in two-pore channel 2-deficient mice
Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice
Cellular Zinc Levels Are Modulated By Trpml1-Tmem163 Interaction.
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV
Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors
Pathological a-synuclein impairs adult-born granule cell development and functional integration in the olfactory bulb
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
STIM1 Controls Neuronal Ca2+ Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior

A Complex Regulatory Network Coordinating Cell Cycles During C. elegans Development Is Revealed by a Genome-Wide RNAi Screen

CNS Axons Globally Increase Axonal Transport after Peripheral Conditioning
Multiparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo
Rapid adaptive optical recovery of optimal resolution over large volumes
Functional Architecture of an Optic Flow-Responsive Area that Drives Horizontal Eye Movements in Zebrafish
Side-Chain to Main-Chain Hydrogen Bonding Controls the Intrinsic Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix
NMDA Receptor-Dependent Multidendrite Ca2+ Spikes Required for Hippocampal Burst Firing In Vivo

Age-dependent changes in mitochondrial morphology and volume are not predictors of lifespan

A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network
Local domains of motor cortical activity revealed by fiber-optic calcium recordings in behaving nonhuman primates


A Photoswitchable Neurotransmitter Analogue Bound to Its Receptor
Sick Sinus Syndrome in HCN1-Deficient Mice
Coordination of Cell Proliferation and Cell Fate Determination by CES-1 Snail
Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2
The Cleavage Domain of the Amyloid Precursor Protein Transmembrane Helix Does Not Exhibit Above-Average Backbone Dynamics
cGMP Accumulation Causes Photoreceptor Degeneration in CNG Channel Deficiency: Evidence of cGMP Cytotoxicity Independently of Enhanced CNG Channel Function
A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA during Cytokinesis
CATP-6, a C. elegans Ortholog of ATP13A2 PARK9, Positively Regulates GEM-1, an SLC16A Transporter
Multibranch activity in basal and tuft dendrites during firing of layer 5 cortical neurons in vivo
Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans
Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion
Gene replacement therapy for retinal CNG channelopathies
Reactivation of the Same Synapses during Spontaneous Up States and Sensory Stimuli
Self-interaction of transmembrane helices representing pre-clusters from the human single-span membrane proteins
Studies toward the Biomimetic Total Synthesis of (−)-PF-1018
Optical modulation of neurotransmission using calcium photocurrents through the ion channel LiGluR
Making Waves: Initiation and Propagation of Corticothalamic Ca2+ Waves In Vivo
Optical control of metabotropic glutamate receptors
Odorant-evoked electrical responses in Grueneberg ganglion neurons rely on cGMP-associated signaling proteins
Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes
Up-regulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channel 3 (HCN3) by Specific Interaction with K+ Channel Tetramerization Domain-containing Protein 3 (KCTD3)
Structural Properties of Model Phosphatidylcholine Flippases
Sequential Photo-bleaching to Delineate Single Schwann Cells at the Neuromuscular Junction
Recombinant Expression, Biophysical Characterization, and Cardiolipin-Induced Changes of Two Caenorhabditis elegans Cytochrome c Proteins


The Backbone Dynamics of the Amyloid Precursor Protein Transmembrane Helix Provides a Rationale for the Sequential Cleavage Mechanism of γ‑Secretase
Characterization of neurite outgrowth and ectopic synaptogenesis in response to photoreceptor dysfunction
In Vivo Imaging of Disease-Related Mitochondrial Dynamics in a Vertebrate Model System
Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency
LOTOS-based two-photon calcium imaging of dendritic spines in vivo
Complex Regulation of Voltage-dependent Activation and Inactivation Properties of Retinal Voltage-gated Cav1.4 L-type Ca2+ Channels by Ca2+-binding Protein 4 (CaBP4)
Biocompatibility of a genetically encoded calcium indicator in a transgenic mouse model
Gene Therapy Restores Vision and Delays Degeneration in the CNGB1-/- Mouse Model of Retinitis Pigmentosa
Dendritic spines: from structure to in vivo function
Regulation of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN) Channel Activity by cCMP
Critical role of soluble amyloid-β for early hippocampal hyperactivity in a mouse model of Alzheimer’s disease
Role of TRPML and Two-Pore Channels in Endolysosomal Cation Homeostasis
Staged decline of neuronal function in vivo in an animal model of Alzheimer's disease
Endoplasmic Reticulum Stress-associated Cone Photoreceptor Degeneration in Cyclic Nucleotide-gated Channel Deficiency
Imaging Calcium in Neurons
Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis
CNGA3 Deficiency Affects Cone Synaptic Terminal Structure and Function and Leads to Secondary Rod Dysfunction and Degeneration


Exploring HCN channels as novel drug targets
The Role of HCN Channels in Ventricular Repolarization
Spatial constraints dictate glial territories at murine neuromuscular junctions
HCN3 Contributes to the Ventricular Action Potential Waveform in the Murine Heart
Chemo- and Thermosensory Responsiveness of Grueneberg Ganglion Neurons Relies on Cyclic Guanosine Monophosphate Signaling Elements
Dendritic coding of multiple sensory inputs in single cortical neurons in vivo
Development of Direction Selectivity in Mouse Cortical Neurons
CNGA3: A Target of Spinal Nitric Oxide/cGMP Signaling and Modulator of Inflammatory Pain Hypersensitivity
Functional mapping of single spines in cortical neurons in vivo
Near-infrared branding efficiently correlates light and electron microscopy
In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration
A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis
Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds
The cGMP-Dependent Protein Kinase II Is an Inhibitory Modulator of the Hyperpolarization-Activated HCN2 Channel
Rescue of Progranulin Deficiency Associated with Frontotemporal Lobar Degeneration by Alkalizing Reagents and Inhibition of Vacuolar ATPase
mGluR1/TRPC3-mediated Synaptic Transmission and Calcium Signaling in Mammalian Central Neurons
A key role for cyclic nucleotide gated (CNG) channels in cGMP-related retinitis pigmentosa
In vivo two-photon imaging of sensory-evoked dendritic calcium signals in cortical neurons
HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path
The Glutamic Acid-Rich Protein Is a Gating Inhibitor of Cyclic Nucleotide-Gated Channels


Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
Planar Patch Clamp Approach to Characterize Ionic Currents from Intact Lysosomes
Restoration of Cone Vision in the CNGA3−/− Mouse Model of Congenital Complete Lack of Cone Photoreceptor Function
Inhibition of mitochondrial fusion by Alpha-synuclein is rescued by PINK1 Parkin and DJ-1
Altered synaptic plasticity and behavioral abnormalities in CNGA3-deficient mice
Transmembrane Protein 147 (TMEM147) Is a Novel Component of the Nicalin-NOMO Protein Complex
Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain
An Olfactory Subsystem that Detects Carbon Disulfide and Mediates Food-Related Social Learning
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels
Bepridil and Amiodarone Simultaneously Target the Alzheimer's Disease beta - and gamma-Secretase via Distinct Mechanisms
Genetic Reactivation of Cone Photoreceptors Restores Visual Responses in Retinitis Pigmentosa
Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of gamma-Secretase-Mediated Intramembrane Proteolysis
Grueneberg Ganglion Neurons Are Finely Tuned Cold Sensors
Induction of STAT3-related genes in fast degenerating cone photoreceptors of cpfl1 mice
Christian Haass received an honorary doctorate from the University of Zurich
Dendritic organization of sensory input to cortical neurons in vivo
Methylene blue fails to inhibit Tau and polyglutamine protein-dependent toxicity in zebrafish
Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5′-untranslated region
Beta-amyloid precursor protein mutants respond to gamma-secretase modulators
Transgenic Zebrafish as a Novel Animal Model to Study Tauopathies and Other Neurodegenerative Disorders in vivo
The cyclic nucleotide-gated ion channel CNGA3 contributes to coolness-induced responses of Grueneberg ganglion neurons
Rapid time course of action potentials in spines and remote dendrites of mouse visual cortex neurons
The Retinitis Pigmentosa Mutation c.3444+1G>A in CNGB1 Results in Skipping of Exon 32
In Vivo Analysis of Cone Survival in Mice


Requirement for Small Side Chain Residues within the GxGD-Motif of Presenilin for gamma-Secretase Substrate Cleavage
Adult generation of glutamatergic olfactory bulb interneurons
AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
Activity-dependent plasticity of developing climbing fiber–Purkinje cell synapses
Calmodulin is a functional regulator of CAV1.4 l-type CA2+ channels
Sparsification of neuronal activity in the visual cortex at eye-opening
Hyperpolarization-Activated Cation Channels: From Genes to Function
Cyclic Nucleotide-Gated Channels
The two-pore channel TPCN2 mediates NAADP-dependent Ca2+-release from lysosomal stores
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin.
Conditional Deletion of ß1-Integrin in Astroglia Causes Partial Reactive Gliosis
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
Cyclic Nucleotide-regulated Cation Channels
Substrate Requirements for SPPL2b-dependent Regulated Intramembrane Proteolysis
HCN channels : Structure, cellular regulation and physiological function
Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain via Brain-Derived Neurotrophic Factor Signaling
Purification, Pharmacological Modulation, and Biochemical Characterization of Interactors of Endogenous Human γ-Secretase
Vision tests in the mouse: Functional phenotyping with electroretinography
Hyperpolarization-Activated Cation Channels: From Genes to Function


Chemical Cross-linking Provides a Model of the y-Secretase Complex Subunit Architecture and Evidence for Close Proximity of the C-terminal Fragment of Presenilin with APH-1
Identification of neural progenitor pools by E(Spl) factors in the embryonic and adult brain
Ex vivo imaging of motor axon dynamics in murine triangularis sterni explants
MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary
Axonal Projections Originating From Raphe Serotonergic Neurons in the Developing and Adult Zebrafish, Danio rerio, Using Transgenics To Visualize Raphe-Specific pet1 Expression
Mechanisms of metabotropic glutamate receptor-mediated synaptic signalling in cerebellar Purkinje cells
Comparative Analysis of Serotonin Receptor (HTR1A/HTR1B Families) and Transporter (slc6a4a/b) Gene Expression in the Zebrafish Brain
Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex
Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer’s Disease
Lysosomal Activity Associated with Developmental Axon Pruning
Intramembrane Proteolysis of GxGD-type Aspartyl Proteases is slowed by a Familial Alzheimer Disease-like Mutation
Gsk3β/PKA and Gli1 regulate the maintenance of neural progenitors at the midbrain-hindbrain boundary in concert with E(Spl) factor activity
TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination
NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain
Fgf signaling in the zebrafish adult brain: Association of Fgf activity with ventricular zones but not cell proliferation
Intramembrane Proteolysis by gamma-Secretase
Regulatory RNA goes awry in Alzheimer’s disease
Development of Presynaptic Inhibition Onto Retinal Bipolar Cell Axon Terminals Is Subclass-Specific
A Novel Sorting Nexin Modulates Endocytic Trafficking and alpha-Secretase Cleavage of the Amyloid Precursor Protein
The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases
Prospective isolation of functionally distinct radial glial subtypes—Lineage and transcriptome analysis
Homosynaptic Long-Term Synaptic Potentiation of the "Winner" Climbing Fiber Synapse in developing Purkinje Cells
Adult Neurogenesis Requires Smad4-Mediated Bone Morphogenic Protein Signaling in Stem Cells


Loss-of-Function of Human PINK1 Results in Mitochondrial Pathology and Can Be Rescued by parkin
FTLD-U linked missense mutations in the progranulin gene reduce progranulin production and secretion
Regulated Intramembrane Proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/b
Generation of Aß38 and Aß42 is independendently and differentially affected by FAD-associated presenilin mutations and gamma-secretase modulation
Function and Dysfunction of CNG Channels: Insights from Channelopathies and Mouse Models
Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium
Active gamma-secretase complexes contain only one of each component
Endoplasmic reticulum retetion of the gamma-secretase complex component Pen2 by Rer1
The Nicastrin-like Protein Nicalin Regulates Assembly and Stability of the Nicalin-Nodal Modulator (NOMO) Membrane Protein Complex
TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry