Research Area F - Publications 2009

Journal of Neurochemisty, 2009, 112, 4, 940 - 50 published on 15.12.2009
Journal of Neurochmisry, online article


γ-Secretase is a pivotal intramembrane-cleaving protease complex and important drug target for Alzheimer's disease. The protease not only releases small peptides, such as the amyloid-β peptide, which drives Alzheimer's disease pathogenesis, but also intracellular domains, which can have critical functions in nuclear signaling. Unlike typical aspartyl proteases, ...