Research Area F - Publications 2007

J. Neurosci., 2007, 27(45), 12413-18 published on 07.11.2007
www.jneurosci.org, online article
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Degeneration of dopaminergic neurons in the substantia nigra is characteristic for Parkinson’s disease (PD), the second most common neurodegenerative disorder. Mitochondrial dysfunction is believed to contribute to the etiology of PD. Although most cases are sporadic, recent evidence points to anumberof genes involved in familial variants of PD.Amongthem, a ...

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J. Biol. Chem., 2007, doi/10.1074/jbc.M705115200, 1-13 published on 05.11.2007
http://www.jbc.org, online article
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Loss of function mutations in progranulin cause tau-negative frontotemporal lobar degeneration with ubiquitin positive inclusions. A major protein component of these inclusions is TDP-43, which becomes hyperphosphorylated, ubiquitinated and cleaved to generate C-terminal fragments, which apparently translocate from nuclei to the cytoplasm. Most progranulin ...

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J. Biol. Chem., 2007, doi/10.1074/jbc.M706661200, published on 25.10.2007
http://www.jbc.org, online article
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Presenilin, the catalytic component of the gamma-secretase complex, type IV prepilin peptidases and signal peptide peptidase (SPP) are the founding members of the family of intramembrane cleaving GxGD aspartyl proteases. SPP-like (SPPL) proteases, such as SPPL2a, b, and c and SPPL3 also belong to the GxGD family. In contrast to gamma-secretase, where numerous ...

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EMBO reports, 2007, 1-6 published on 24.10.2007
www.jbc.org, online article
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Alzheimer's disease (AD) amyloid beta-peptide (Aß) is generated via proteolytic processing of the ß-amyloid precursor protein (APP) by ß- and gamma-secretase. gamma-Secretase can be blocked by selective inhibitors but can also be modulated by a subset of non-steroidal anti-inflammatory drugs (NSAIDs) including sulindac sulfide. These drugs selectively reduce the ...

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