Research Area C

2017

Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator

The glia of the adult Drosophila nervous system

A two-component adhesive: Tau fibrils arise from a combination of a well-defined motif and conformationally flexible interactions

Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in Drosophila

A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins

2016

Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions

In-vivo PET imaging of the "cancer integrin" αvβ6 using gallium-68 labelled cyclic RGD nonapeptides

Structural basis for ArfA–RF2-mediated translation termination on mRNAs lacking stop codons

Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea

Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation

Recognition of the 3′ splice site RNA by the U2AF heterodimer involves a dynamic population shift

Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing

Importance of cycle timing for the function of the molecular chaperone Hsp90

Structural biology of the import pathways of peroxisomal matrix proteins

DNA annealing by Redβ is insufficient for homologous recombination and the additional requirements involve intra- and inter-molecular interactions

Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions

Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex

Bacterial Protein Synthesis as a Target for Antibiotic Inhibition

A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest

Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome

Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length

Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding

Solution structure and binding specificity of the p63 DNA binding domain

RIG-I-Like Receptors: One STrEP Forward

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

Invited review: Architectures and mechanisms of ATP binding cassette proteins

Variation of Specific Activities of Ga-68-Aquibeprin and Ga-68-Avebetrin Enables Selective PET-Imaging of Different Expression Levels of Integrins α5β1 and αvβ3

The ABC of Ribosome-Related Antibiotic Resistance

αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating

Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40

Immobilization of soluble protein complexes in MAS solid-state NMR: Sedimentation versus viscosity

Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation

Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation

Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer’s Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity

Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50

Translation regulation via nascent polypeptide-mediated ribosome stalling

A Stable Mutant Predisposes Antibody Domains to Amyloid Formation through Specific Non-Native Interactions

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress

Structure of the mammalian antimicrobial peptide Bac7(1–16) bound within the exit tunnel of a bacterial ribosome

Improved Accuracy from Joint X-ray and NMR Refinement of a Protein–RNA Complex Structure

Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction

RNA recognition by Roquin in posttranscriptional gene regulation

2015

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome

Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity

Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands

Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties

Restoring Resolution in Biological Solid-State NMR under Conditions of Off-Magic-Angle Spinning

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA

Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction

Blast from the Past: Reassessing ForgottenTranslation Inhibitors, Antibiotic Selectivity, and ResistanceMechanisms to Aid Drug Development

Blast from the Past: Reassessing Forgotten Translation Inhibitors, Antibiotic Selectivity, and Resistance Mechanisms to Aid Drug Development

The Antibody Light-Chain Linker Is Important for Domain Stability and Amyloid Formation

Stall no more at polyproline stretches with the translation elongation factors EF-P and IF-5A

Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling

Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites

Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex

In vivo biokinetic and metabolic characterization of the 68Ga-labelled α5β1-selective peptidomimetic FR366

Bioactive compounds immobilized on Ti and TiNbHf: AFM-basedinvestigations of biofunctionalization efficiency and cell adhesion

Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client

Structural biology of the import pathways of peroxisomalmatrix proteins

Towards the molecular mechanism of the integration of peroxisomal membrane proteins

Structural Mechanism of the Interaction of Alzheimer Disease A Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide

Entropic Contribution of Elongation Factor P to Proline Positioning at the Catalytic Center of the Ribosome

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides?

Efficient segmental isotope labeling of multi-domain proteins using Sortase A

Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1

Minimal Synthetic Cells to Study Integrin-Mediated Adhesion

RNA degradation paths in a 12-subunit nuclear exosome complex

Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors

Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3-dATP

Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3

A Crystallin Fold in the Interleukin-4-inducing Principle of Schistosoma mansoni Eggs (IPSE/α-1) Mediates IgE Binding for Antigen-independent Basophil Activation

Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases

Deciphering the protein-RNA recognition code: Combining large-scale quantitative methods with structural biology
Structure of the catalytic domain of Mre11 from Chaetomium thermophilum
Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A
Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism
The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation

Segregation Versus Colocalization: Orthogonally Functionalized Binary Micropatterned Substrates Regulate the Molecular Distribution in Focal Adhesions

Structural and Functional Analysis of the Signal-Transducing Linker in the pH-Responsive One-Component System CadC of Escherichia coli

Architecture of the Ubiquitylation Module of the Yeast Ccr4-Not Complex

Enantiomeric Cyclic Peptides with Different Caco-2 Permeability Suggest Carrier-Mediated Transport
A novel RNA binding surface of the TAM domain of TIP5/BAZ2A mediates epigenetic regulation of rRNA genes
Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling
Structural Characterization of LRRK2 Inhibitors
Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å resolution
Bruce Merrifield Award & Murray Goodman Endowed Lectureship for CIPSM researcher Horst Kessler

Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules

Mimicking bone extracellular matrix: Integrin-binding peptidomimetics enhance osteoblast-like cells adhesion, proliferation, and differentiation on titanium
Chapter Eleven – Structural Analysis of Protein–RNA Complexes in Solution Using NMR Paramagnetic Relaxation Enhancements
Dynamic RNA world
Structural Basis for Dodecameric Assembly States and Conformational Plasticity of the Full-Length AAA+ ATPases Rvb1·Rvb2
Disclosing the CXCR4 Expression in Lymphoproliferative Diseases by Targeted Molecular Imaging
The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex
Arginine-rhamnosylation as new strategy to activate translation elongation factor P
Cloning, expression and purification of the human Islet Amyloid Polypeptide (hIAPP) from Escherichia coli
A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease
Site-Specific Solid-State NMR Studies of “Trigger Factor” in Complex with the Large Ribosomal Subunit 50S
Perspectives for sensitivity enhancement in proton-detected solid-state NMR of highly deuterated proteins by preserving water magnetization
Direct prediction of residual dipolar couplings of small molecules in a stretched gel by stochastic molecular dynamics simulations
Access to Cα Backbone Dynamics of Biological Solids by 13C T1 Relaxation and Molecular Dynamics Simulation

2014

Breaking the protein-RNA recognition code
Molecular architecture of the HerA–NurA DNA double-strand break resection complex

Annotation of genomics data using bidirectional hidden Markov models unveils variations in Pol II transcription cycle

Detection of Hydrogen Bonds in Dynamic Regions of RNA by NMR Spectroscopy
Differential inhibition of Arabidopsis superoxide dismutases by peroxynitrite-mediated tyrosine nitration
Structure of the Rad50 DNA double-strand break repair protein in complex with DNA
A Conserved Proline Triplet in Val-tRNA Synthetase and the Origin of Elongation Factor P
Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation
The bacterial translation stress response
Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure
Artificial Accelerators of the Molecular Chaperone Hsp90 Facilitate Rate-Limiting Conformational Transitions
ATP puts the brake on DNA double-strand break repair
Structural basis for the assembly of the Sxl–Unr translation regulatory complex
Transcriptome Maps of mRNP Biogenesis Factors Define Pre-mRNA Recognition
A Novel Protein-Protein Interaction in the RES (REtention and Splicing) Complex
Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site
Molecular Basis for Coordinating Transcription Termination with Noncoding RNA Degradation
A Residue-specific Shift in Stability and Amyloidogenicity of Antibody Variable Domains
Structural Studies of DNA End Detection and Resection in Homologous Recombination
T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell
Autophagic Clearance of PolyQ Proteins Mediated by Ubiquitin-Atg8 Adaptors of the Conserved CUET Protein Family
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation
Protein Folding by Interaction
NMR approaches for structural analysis of multidomain proteins and complexes in solution
Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia
Site-specific analysis of heteronuclear Overhauser effects in microcrystalline proteins
A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair
The Integrin Ligand c(RGDf(NMe)Nal) Reduces Neointimal Hyperplasia in a Polymer-Free Drug-Eluting Stent System
Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions
Rational Improvement of the Affinity and Selectivity of Integrin Binding of Grafted Lasso Peptides
The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins
Rpb4 Subunit Functions Mainly in mRNA Synthesis by RNA Polymerase II
Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production
Periodic mRNA synthesis and degradation co-operate during cell cycle gene expression
In Vivo Ligands of MDA5 and RIG-I in Measles Virus- Infected Cells
The dynamic duo: Combining NMR and small angle scattering in structural biology
Entrapment of DNA in an intersubunit tunnel system of a single-stranded DNA-binding protein
Transient Electrostatic Interactions Dominate the Conformational Equilibrium Sampled by Multidomain Splicing Factor U2AF65: A Combined NMR and SAXS Study
Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome
Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain
Benefits of NOPO As Chelator in Gallium-68 Peptides, Exemplified by Preclinical Characterization of 68Ga-NOPO−c(RGDfK
Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1
Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide
Pharmacophoric Modifications Lead to Superpotent αvβ3 Integrin Ligands with Suppressed α5β1 Activity
Modulation of the Hsp90 Chaperone Cycle by a Stringent Client Protein
Next-Generation Heteronuclear Decoupling for High-Field Biomolecular NMR Spectroscopy
Dynamics in the solid-state: perspectives for the investigation of amyloid aggregates, membrane proteins and soluble protein complexes
Ribosome Rescue, Nearing the End
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
A new system for naming ribosomal proteins
Investigation of early cell–surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium–niobium alloy surfaces
Tetracycline antibiotics and resistance mechanisms
RNA polymerase II termination involves C-terminal-domain tyrosine dephosphorylation by CPF subunit Glc7
Ribosome-targeting antibiotics and mechanisms of bacterial resistance
A novel intermediate in transcription initiation by human mitochondrial RNA polymerase
The Cyclic Cystine Ladder of Theta-Defensins as a Stable, Bifunctional Scaffold: A Proof-of-Concept Study Using the Integrin-Binding RGD Motif.

2013

Studying Weak and Dynamic Interactions of Posttranslationally Modified Proteins using Expressed Protein Ligation
Transcriptome Surveillance by Selective Termination of Noncoding RNA Synthesis

Recruitment of TREX to the Transcription Machinery by Its Direct Binding to the Phospho-CTD of RNA Polymerase II

A Novel Pex14 Protein-interacting Site of Human Pex5 Is Critical for Matrix Protein Import into Peroxisomes
The RNA Polymerase II C-terminal Domain-Interacting Domain of Yeast Nrd1 Contributes to the Choice of Termination Pathway and Couples to RNA Processing by the Nuclear Exosome
Insights into the Mode of Action of Novel Fluoroketolides, Potent Inhibitors of Bacterial Protein Synthesis
RNA polymerase I structure and transcription regulation
Cap Completion and C-Terminal Repeat Domain Kinase Recruitment Underlie the Initiation-Elongation Transition of RNA Polymerase II
Interface Immobilization Chemistry of cRGD-based Peptides Regulates Integrin Mediated Cell Adhesion
Integrin modulators: a patent review
Global Analysis of Eukaryotic mRNA Degradation Reveals Xrn1-Dependent Buffering of Transcript Levels
Structure of human mitochondrial RNA polymerase elongation complex
Opening windows into the cell: focused-ion-beam milling for cryo-electron tomography
Selective Imaging of the Angiogenic Relevant Integrins α5β1 and αvβ3
Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue
Amythiamicin D and Related Thiopeptides as Inhibitors of the Bacterial Elongation Factor EF-Tu: Modification of the Amino Acid at Carbon Atom C2 of Ring C Dramatically Influences Activity
Structure and Subunit Topology of the INO80 Chromatin Remodeler and Its Nucleosome Complex
On the use of the antibiotic chloramphenicol to target polypeptide chain mimics to the ribosomal exit tunnel
Unveiling the Long-Held Secrets of the 26S Proteasome
Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P
Tumor targeting via integrin ligands
The Glycophorin A Transmembrane Sequence within Integrin αvβ3 Creates a Non-Signaling Integrin with Low Basal Affinity That Is Strongly Adhesive under Force
Cryogenic solid state NMR studies of fibrils of the Alzheimer’s disease amyloid-β peptide: perspectives for DNP
Model of the Mediator middle module based on protein cross-linking
Cryo-electron tomography: The challenge of doing structural biology in situ
NMR Spectroscopy of Soluble Protein Complexes at One Mega-Dalton and Beyond
A Molecular Toolkit for the Functionalization of Titanium-Based Biomaterials That Selectively Control Integrin-Mediated Cell Adhesion
High-resolution structures of the IgM Fc domains reveal principles of its hexamer formation
Proton-Detected Solid-State NMR Spectroscopy at Aliphatic Sites: Application to Crystalline Systems
The RNA polymerase trigger loop functions in all three phases of the transcription cycle
Comparison of cyclic RGD peptides for αvβ3 integrin detection in a rat model of myocardial infarction
Crystal Structure of Human TWEAK in Complex with the Fab Fragment of a Neutralizing Antibody Reveals Insights into Receptor Binding
Hydrogen bonding involving side chain exchangeable groups stabilizes amyloid quarternary structure
Structures of the human and Drosophila 80S ribosome
Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan
Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocation
A Cyclen-Based Tetraphosphinate Chelator for the Preparation of Radiolabeled Tetrameric Bioconjugates
Species-specific detection of the antiviral small-molecule compound CMA by STING
The Mechanism of Denaturation and the Unfolded State of the α-Helical Membrane-Associated Protein Mistic
Oral Disinfectants Inhibit Protein–Protein Interactions Mediated by the Anti-Apoptotic Protein Bcl-xL and Induce Apoptosis in Human Oral Tumor Cells
Nascent peptides that block protein synthesis in bacteria
Combining NMR and small angle X-ray and neutron scattering in the structural analysis of a ternary protein-RNA complex
Struggling to let go: a non-coding RNA directs its own extension and destruction
Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis
Protein–RNA Interfaces Probed by 1H-Detected MAS Solid-State NMR Spectroscopy
Translational repression of thymidylate synthase by targeting its mRNA
Production of a de-novo designed antimicrobial peptide in Nicotiana benthamiana
Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex
Biselectivity of isoDGR Peptides for Fibronectin Binding Integrin Subtypes α5β1 and αvβ6: Conformational Control through Flanking Amino Acids
Functionalizing αvβ3- or α5β1-Selective Integrin Antagonists for Surface Coating: A Method To Discriminate Integrin Subtypes In Vitro
Structural and Functional Analysis of the DEAF-1 and BS69 MYND Domains
Paramyxovirus V Proteins Disrupt the Fold of the RNA Sensor MDA5 to Inhibit Antiviral Signaling
FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of αv and β3 integrin transcription.
The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain

2012

Structure and function of the initially transcribing RNA polymerase II–TFIIB complex
Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches
Funktionalisierung αvβ3- oder α5β1-selektiver Integrinantagonisten für die Oberflächenbeschichtung: ein Hilfsmittel zur Unterscheidung von Integrinsubtypen in vitro
Promiscuous behaviour of archaeal ribosomal proteins: Implications for eukaryotic ribosome evolution
Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 30-splice site recognition
N-Methylierung von Peptiden und Proteinen: ein wichtiges Element für die Regulation biologischer Funktionen
Optimal degree of protonation for 1H detection of aliphatic sites in randomly deuterated proteins as a function of the MAS frequency
Structural basis for TetM-mediated tetracycline resistance
Structural Properties of EGCG-Induced, Nontoxic Alzheimer's Disease Aβ Oligomers
A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity
Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin avb3-selective cyclic RGD peptides
CTD Tyrosine Phosphorylation Impairs Termination Factor Recruitment to RNA Polymerase II
Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
A Movie of RNA Polymerase II Transcription
Cell adhesion and proliferation on RGD-modified recombinant spider silk proteins
MC EMiNEM Maps the Interaction Landscape of the Mediator
Dynamics in multi-domain protein recognition of RNA
Lys34 of translation elongation factor EF-P is hydroxylated by YfcM
Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling
EMBO welcomes 3 CIPSM scientists as new members
An Asymmetric Dimer as the Basic Subunit in Alzheimer’s Disease Amyloid β Fibrils
Swi2/Snf2 remodelers: hybrid views on hybrid molecular machines
Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage
Structural and Functional Organization of the Ska Complex, a Key Component of the Kinetochore-Microtubule Interface
Comparative Dynamic Transcriptome Analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation
Substrate Transport Activation Is Mediated through Second Periplasmic Loop of Transmembrane Protein MalF in Maltose Transport Complex of Escherichia coli
Dynamic Architecture of a Minimal RNA Polymerase II Open Promoter Complex
Crosslinking-MS analysis reveals RNA polymerase I domain architecture and basis of rRNA cleavage
Radiolabelled RGD peptides for imaging and therapy
Structural basis of highly conserved ribosome recycling in eukaryotes and archaea
Solid-phase-assisted synthesis of targeting peptide–PEG–oligo(ethane amino)amides for receptor-mediated gene delivery
Conservation between the RNA Polymerase I, II, and III Transcription Initiation Machineries
Target- and Resistance-Based Mechanistic Studies with TP-434, a Novel Fluorocycline Antibiotic
A structural perspective on Mediator function
hnRNP A1 Proofreads 30 Splice Site Recognition by U2AF
Synthesis of N-methylated cyclic peptides
Processive RNA decay by the exosome
Characterization of Membrane Proteins in Isolated Native Cellular Membranes by Dynamic Nuclear Polarization Solid-State NMR Spectroscopy without Purification and Reconstitution
Synthesis and Conformational Analysis of Efrapeptins
Chromodomains read the arginine code of post-translational targeting
The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
Structural and Mechanistic Implications of Metal-Binding in the Small Heat-Shock Protein αB-Crystallin
Solution Structure and Molecular Interactions of Lamin B Receptor Tudor Domain
Ultra-high resolution in MAS solid-state NMR of perdeuterated proteins: Implications for structure and dynamics
Sensing of viral nucleic acids by RIG-I: From translocation to translation

2011

On the specificity of antibiotics targeting the large ribosomal subunit
Tailoring of Integrin Ligands: Probing the Charge Capability of the Metal Ion-Dependent Adhesion Site
Spectroscopically Well-Characterized RGD Optical Probe as a Prerequisite for Lifetime-Gated Tumor Imaging
Assignment strategies for aliphatic protons in the solid-state in randomly protonated proteins
Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins
The DARC site: a database of aligned ribosomal complexes
The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling
Increasing αvβ3 Selectivity of the Anti-Angiogenic Drug Cilengitide by N-Methylation
Increasing alpha-v-beta-3 Selectivity of the Anti-Angiogenic Drug Cilengitide by N-Methylation
Structure of human mitochondrial RNA polymerase
Molecular basis of Rrn3-regulated RNA polymerase I initiation and cell growth
ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex
A Glycopeptide Dendrimer Inhibitor of the Galactose-Specific Lectin LecA and of Pseudomonas aeruginosa Biofilms
Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4
Introducing Lasso Peptides as Molecular Scaffolds for Drug Design: Engineering of an Integrin Antagonist
Structural analysis of the interaction between Hsp90 and the tumor suppressor protein p53
Nuclear actin-related proteins take shape
Strategies for the structural analysis of multi-protein complexes: Lessons from the 3D-Repertoire project
Telethonin Deficiency Is Associated With Maladaptation to Biomechanical Stress in the Mammalian Heart
1H, 13C, 15N and 31P chemical shift assignments of a human Xist RNA A-repeat tetraloop hairpin essential for X-chromosome inactivation
1H, 13C, 15N and 31P chemical shift assignments of a human Xist RNA A-repeat tetraloop hairpin essential for X-chromosome inactivation
PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand
How to make stripes: deciphering the transition from non-periodic to periodic patterns in Drosophila segmentation
Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF
Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP
Differential Effects of Thiopeptide and Orthosomycin Antibiotics on Translational GTPases
Evolution of Two Modes of Intrinsic RNA Polymerase Transcript Cleavage
Optimal 2H rf Pulses and 2H–13C Cross-Polarization Methods for Solid-State 2H MAS NMR of Perdeuterated Proteins
A Conformational Switch Underlies ClpP Protease Function
Proton-Detected Solid-State NMR Spectroscopy of Fibrillar and Membrane Proteins
1H, 13C and 15N chemical shift assignments of IPSEΔNLS
Iwr1 Directs RNA Polymerase II Nuclear Import
The Effect of Multiple N-Methylation on Intestinal Permeability of Cyclic Hexapeptides
Cryo-EM structure of the ribosome–SecYE complex in the membrane environment
Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization
Structural biochemistry of nuclear actin-related proteins 4 and 8 reveals their interaction with actin
N-Methylated sst2 Selective Somatostatin Cyclic Peptide Analogue as a Potent Candidate for Treating Neurogenic Inflammation
A Cytoplasmic Complex Mediates Specific mRNA Recognition and Localization in Yeast
The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair
Structural Analysis of Large Protein Complexes Using Solvent Paramagnetic Relaxation Enhancements
Structure Calculation from Unambiguous Long-Range Amide and Methyl 1H−1H Distance Restraints for a Microcrystalline Protein with MAS Solid-State NMR Spectroscopy
Take a look at Karl-Peter Hopfner's "Sensing DNA Damage" Cell Movie
NMR and small-angle scattering-based structural analysis of protein complexes in solution
Architecture of the RNA polymerase–Spt4/5 complex and basis of universal transcription processivity
Structure and VP16 binding of the Mediator Med25 activator interaction domain
Structural basis of RNA polymerase II backtracking, arrest and reactivation
Bacterial Inclusion Bodies of Alzheimer’s Disease b-Amyloid Peptides Can Be Employed To Study Native-Like Aggregation Intermediate States
The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling
Peptides in the Ribosomal Tunnel Talk Back
SecM-Stalled Ribosomes Adopt an Altered Geometry at the Peptidyl Transferase Center
PET Imaging of Integrin alpha-V-beta-3 Expression
Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in yeast
pH-Dependent Dimerization and Salt-Dependent Stabilization of the N-terminal Domain of Spider Dragline Silk-Implications for Fiber Formation
Stable functionalized PEGylated quantum dots micelles with a controlled stoichiometry
Proteomic Characterization of Archaeal Ribosomes Reveals the Presence of Novel Archaeal-Specific Ribosomal Proteins
Latest News

2010

Architecture of the RNA polymerase II–TFIIF complex revealed by cross-linking and mass spectrometry
Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites
Structure and DNA-binding activity of the Pyrococcus furiosus SMC protein hinge domain
CIPSM's Daniel Wilson received the EMBO Young Investigators Award for his work on new antibiotics
RNA polymerase II–TFIIB structure and mechanism of transcription initiation
Reversible and Controllable Nanolocomotion of an RNA-Processing Machinery
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosome
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-Å resolution
Mechanism of replication blocking and bypass of Y-family polymerase Eta by bulky acetylaminofluorene DNA adducts
The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress
NCO-sP(EO-stat-PO) surface coatings preserve biochemical properties of RGD peptides
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1
Optimized Measurement Temperature Gives Access to the Solution Structure of a 49 kDa Homohexameric Beta - Propeller
Structural Basis for Translational Stalling by Human Cytomegalovirus and Fungal Arginine Attenuator Peptide
A tandem SH2 domain in transcription elongation factor Spt6 binds the phosphorylated RNA polymerase II CTD
Molecular Basis of RNA Polymerase III Transcription Repression by Maf1
Polymeric Substrates with Tunable Elasticity and Nanoscopically Controlled Biomolecule Presentation
Uniform transitions of the general RNA polymerase II transcription complex
Hsp12 Is an Intrinsically Unstructured Stress Protein that Folds upon Membrane Association and Modulates Membrane Function
RNA Polymerase I Contains a TFIIF-Related DNA-Binding Subcomplex
Structural Basis for Adenylate Kinase Activity in ABC ATPases
Structure of an atypical Tudor domain in the Drosophila Polycomblike protein
Improvement of drug-like properties of peptides: the somatostatin paradigm
Structural Basis for Homodimerization of the Src-associated during Mitosis, 68-kDa Protein (Sam68) Qua1 Domain
Probing Translation with Small-Molecule Inhibitors
The archaeo-eukaryotic primase of plasmid pRN1 requires a helix bundle domain for faithful primer synthesis
Interplay between the Ribosomal Tunnel, Nascent Chain, and Macrolides Influences Drug Inhibition
Nucleocytoplasmic shuttling of the La motif-containing protein Sro9 might link its nuclear and cytoplasmic functions
Towards molecular systems biology of gene transcription and regulation
Multiple N-Methylation of MT-II Backbone Amide Bonds Leads to Melanocortin Receptor Subtype hMC1R Selectivity: Pharmacological and Conformational Studies
A conserved spider silk domain acts as a molecular switch that controls fibre assembly
Structural Analysis of Protein Interfaces from 13C Direct-Detected Paramagnetic Relaxation Enhancements
Cilengitide: The First Anti-Angiogenic Small Molecule Drug Candidate. Design, Synthesis and Clinical Evaluation
Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX
Quantitative analysis of processive RNA degradation by the archaeal RNA exosome
The Impact of Amino Acid Side Chain Mutations in Conformational Design of Peptides and Proteins
Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif
Cell Adhesion Strength Is Controlled by Intermolecular Spacing of Adhesion Receptors
Asymmetric Activation of the Hsp90 Dimer by Its Cochaperone Aha1
An Efficient Protocol for NMR-Spectroscopy-Based Structure Determination of Protein Complexes in Solution
α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel
Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins
Preparation and topology of the Mediator middle module
BclxL Changes Conformation upon Binding to Wild-type but Not Mutant p53 DNA Binding Domain
Coupled chaperone action in folding and assembly of hexadecameric Rubisco
Imaging of integrin avb3 expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography
The Transmembrane Structure of Integrin aIIbb3: Significance for Signal Transduction
Force-induced destabilization of focal adhesions at defined integrin spacings on nanostructured surfaces

2009

Modulation of protein properties in living cells using nanobodies
PSRP1 Is Not a Ribosomal Protein, but a Ribosome-binding Factor That Is Recycled by the Ribosome-recycling Factor (RRF) and Elongation Factor G (EF-G)
Structural Insight into Nascent Polypeptide Chain–Mediated Translational Stalling
Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome
The A–Z of bacterial translation inhibitors
Biosynthesis of the Aminocyclitol Subunit of Hygromycin A in Streptomyces hygroscopicus NRRL 2388
Identification of Distinct Thiopeptide-Antibiotic Precursor Lead Compounds Using Translation Machinery Assays
X-ray structure of Pur-α reveals a Whirly-like fold and an unusual nucleic-acid binding surface
Lessons from structural and biochemical studies on the archaeal exosome
Enhanced SnapShot: Antibiotic Inhibition of Protein Synthesis II
DNA Double-Strand Breaks Come into Focus
A Boost for Sequence Searching
SnapShot: Antibiotic Inhibition of Protein Synthesis I
The torpedo nuclease Rat1 is insufficient to terminate RNA polymerase II in vitro
Molecular basis of transcriptional mutagenesis at 8-oxoguanine
The Final Step of Hygromycin A Biosynthesis, Oxidation of C-5''-Dihydrohygromycin A, Is Linked to a Putative Proton Gradient-Dependent Efflux
Formation of She2p tetramers is required for mRNA binding, mRNP assembly, and localization
Hsp90 is regulated by a switch point in the C-terminal domain
Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences
Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of b-secretase (BACE1)
Helical Growth of the Arabidopsis Mutant tortifolia2 Does Not Depend on Cell Division Patterns but Involves Handed Twisting of Isolated Cells
mRNA Export - An Integrative Component of Gene Expression
Nano positioning system reveals the course of upstream and nontemplate DNA within the RNA polymerase II elongation complex
The Transmembrane Structure of Integrin [alpha]IIb[beta]3: Significance for Signal Transduction
Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II
Structural Basis of Transcription: Mismatch-Specific Fidelity Mechanisms and Paused RNA Polymerase II with Frayed RNA
Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.
Fast and accurate automatic structure prediction with HHpred
An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies
Adhesion Dance with Raver
Breaking the Dogma of the Metal-Coordinating Carboxylate Group in Integrin Ligands: Introducing Hydroxamic Acids to the MIDAS To Tune Potency and Selectivity
Ligands for Mapping αvβ3-Integrin Expression in Vivo
A movie of the RNA polymerase nucleotide addition cycle
Structure and in Vivo Requirement of the Yeast Spt6 SH2 Domain
HHomp—prediction and classification of outer membrane proteins
Non-Hydrolyzable RNA-Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3-Peptidyl tRNA Termini
The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts
Interaction of human heat shock protein 70 with tumor-associated peptides
Sequence context-specific profiles for homology searching
Cytosolic Viral Sensor RIG-I Is a 5′-Triphosphate–Dependent Translocase on Double-Stranded RNA
Structure and Ligand Binding of the Extended Tudor Domain of D. melanogaster Tudor-SN
Impact of Order and Disorder in RGD Nanopatterns on Cell Adhesion
The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA
Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19
Structure–function studies of the RNA polymerase II elongation complex
Time-Resolved Binding of Azithromycin to Escherichia coli Ribosomes
Less Is More for Leaderless mRNA Translation
The Native 3D Organization of Bacterial Polysomes
A Distinct Mode of Interaction of a Novel Ketolide Antibiotic That Displays Enhanced Antimicrobial Activity
Thioredoxin as a fusion tag for carrier-driven crystallization

2008

MicroRNAs Repress Mainly through mRNA Decay
RNA polymerase fidelity and transcriptional proofreading
The archaeal RNA polymerase subunit P and the eukaryotic polymerase subunit Rpb12 are interchangeable in vivo and in vitro
Identification, structure, and functional requirement of the Mediator submodule Med7N/31
Cooperativity in Adhesion Cluster Formation during Initial Cell Adhesion
Phospholipid scramblases and Tubby-like proteins belong to a new superfamily of membrane tethered transcription factors
Cell interactions with hierarchically structured nano-patterned adhesive surfaces
A NMR strategy to unambiguously distinguish nucleic acid hairpin and duplex conformations applied to a Xist RNA A-repeat
Can N-methylated amino acids serve as substitutes for prolines in conformational design of cyclic pentapeptides?
Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2
Dimerization and Protein Binding Specificity of the U2AF Homology Motif of the Splicing Factor Puf60*
The Solution Structure of BMPR-IA Reveals a Local Disorder-to-Order Transition upon BMP-2 Binding
Ulrike Gaul comes to CIPSM! Germany, Munich – the house is rocking.
Screening of fusion partners for high yield expression and purification of bioactive viscotoxins
A nano-positioning system for macromolecular structural analysis
Deuterated polymer gels for measuring anisotropic NMR parameters with strongly reduced artefacts
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning
Perspectives on NMR in drug discovery: a technique comes of age
CIPSM Coordinator Horst Kessler wins Josef Rudinger Award
YEAH! CIPSM-Junior-Group Leader Katja Strässer receives big €-EU-Grant
A new tRNA intermediate revealed on the ribosome during EF4-mediated back-translocation
A structure refinement protocol combining NMR residual dipolar couplings and small angle scattering restraints
Genome-associated RNA Polymerase II Includes the Dissociable Rpb4/7 Subcomplex*
Backbone assignment of the UHM domain of Puf60 free and bound to five ligands
N-Methylation of Peptides: A New Perspective in Medicinal Chemistry
The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity
Induction of Cell Polarization and Migration by a Gradient of Nanoscale Variations in Adhesive Ligand Spacing
Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation
Rational Design of Highly Active and Selective Ligands for the alpha-5-beta-1 Integrin Receptor
Crystallization of RNA polymerase I subcomplex A14/A43 by iterative prediction, probing and removal of flexible regions
The Role of 23S Ribosomal RNA Residue A2451 in Peptide Bond Synthesis Revealed by Atomic Mutagenesis
Isothiocyanate-functionalized RGD peptides for tailoring cell-adhesive surface patterns
Multiplexed Proteomics Mapping of Yeast RNA Polymerase II and III Allows Near-Complete Sequence Coverage and Reveals Several Novel Phosphorylation Sites
The sweetest candy for the virus
Introduction of Functional Groups into Peptides via N-Alkylation
Translational Regulation via L11: Molecular Switches on the Ribosome Turned On and Off by Thiostrepton and Micrococcin
1H, 13C, and 15N chemical shift assignments for the Eps15-EH2-stonin 2 complex
The CLIP/CLAP-HSQC: Pure absorptive spectra for the measurement of one-bond couplings
Phosphorus NMR Spectroscopy as a Versatile Tool for Compound Library Screening
Improving Oral Bioavailability of Peptides by Multiple N-Methylation: Somatostatin Analogues
Role of Ser-340 and Thr-341 in Transmembrane Domain IX of the Na+/Proline Transporter PutP of Escherichia coli in Ligand Binding Transport
Structure of an Archaeal RNA Polymerase
Conformational Preference and Potential Templates of N-Methylated Cyclic Pentaalanine Peptides
Structure of Eukaryotic RNA Polymerases
Assessment of αvβ3 Integrin Expression after Myocarcdial Infarction by Positron Emission Tomography
Structure–function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement
The C-Terminal Regulatory Domain Is the RNA 5`-Triphosphate Sensor of RIG-I
Structure–system correlation identifies a gene regulatory Mediator submodule
Structure of the Eps15–stonin2 complex provides a molecular explanation for EH-domain ligand specificity
Efficient factor VIII affinity purification using a small synthetic ligand
Single-molecule tracking of mRNA exiting from RNA polymerase II

2007

Functional Architecture of RNA Polymerase I
The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP
Site specific phosphorylation of yeast RNA polymerase I
2008 Gottfried Wilhelm Leibniz Prize for CIPSM researcher Elena Conti
Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins
Molecular basis of RNA-dependent RNA polymerase II activity
Allowing an elite
Seeing Cisplatin - Discerning how an anticancer drug meddles with replication, transcription
Mechanism of transcriptional stalling at cisplatindamaged DNA
Structural Aspects of RbfA Action during Small Ribosomal Subunit Assembly
Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase Eta
Multiple N-Methylation by a Designed Approach Enhances Receptor Selectivity
Archaeal transcription: function of an alternative transcription factor B from Pyrococcus furiosus
Structural Biology of RNA Polymerase III: Mass Spectrometry Elucidates Subcomplex Architecture
J-ONLY-TOCSY: Efficient suppression of RDC-induced transfer in homonuclear TOCSY experiments using JESTER-1-derived multiple pulse sequences
Specific Integrin Labeling in Living Cells Using Functionalized Nanocrystals
High-Resolution Structure of a Na+/H+ Antiporter Dimer Obtained by Pulsed Electron Paramagnetic Resonance Distance Measurements
Development of a Peptidomimetic Ligand for Efficient Isolation and Purification of Factor VIII via Affinity Chromatography
Finding the right spot to start transcription
Drosophilia microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1
Multisubunit RNA Polymerases Melt Only a Single DNA Base Pair Downstream of the Active Site
piRNAs-the ancient hunters of genome invaders
The RGD motif in fi bronectin is essential for development but dispensable for fibril assembly
U2AF-homology motif interactions are required for alternative splicing regulation by SPF45
Structural basis for DNA duplex sepration by a superfamily-2 helicase
DNA photodamage recognition by RNA polymerase II
CPD Damage Recognition by Transcribing RNA Polymerase II
CIPSM Movie
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Helmholtz München
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