A Movie of RNA Polymerase II Transcription

Cell, 2012, DOI 10.1016/j.cell.2012.06.006, Volume 149, Issue 7, 1431-1437 published on 22.06.2012

Cell, online article

We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition. The movie reveals open questions about the mechanism of transcription and provides a useful teaching tool.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry