Research Area C - Publications 2020

Cell Rep., [online ahead of print] , DOI:https://doi.org/10.1016/j.celrep.2020.107522
Cell Rep., online article

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Tumor cells orchestrate their microenvironment. Here, we provide biochemical, structural, functional, and clinical evidence that Cathepsin S (CTSS) alterations induce a tumor-promoting immune microenvironment in follicular lymphoma (FL). We found CTSS mutations at Y132 in 6% of FL (19/305). Another 13% (37/286) had CTSS amplification, which was associated with ...

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