Research Area C - Publications 2007

Cell, 2007, Vol. 131, 1260-72 published on 28.12.2007
Cell, online article
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Synthesis of ribosomal RNA (rRNA) by RNA polymerase (Pol) I is the first step in ribosome biogenesis and a regulatory switch in eukaryotic cell growth. Here we report the 12 A° cryoelectron microscopic structure for the complete 14-subunit yeast Pol I, a homology model for the core enzyme, and the crystal structure of the subcomplex A14/43. In the resulting ...

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Molecular Microbiology, 2007, 67 (3), 570-83 published on 16.12.2007
Molecular Microbiology, online article
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In an acidic (pH 5.8) and lysine-rich environment Escherichia coli induces expression of the cadBA operon which encodes CadA, catalysing the decarboxylation of lysine to cadaverine, and CadB, the lysine/cadaverine antiporter. cadBA expression is dependent on CadC, a membrane-integrated transcriptional activator which belongs to the ToxR-like protein family and ...

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Nucleic Acids Research, 2007, doi: 10.1093/nar/gkm1093, 793-802 published on 15.12.2007
Nucleic Acids Research, online article
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All nuclear RNA polymerases are phosphoprotein complexes. Yeast RNA polymerase I (Pol I) contains approximately 15 phosphate groups, distributed to 5 of the 14 subunits. Information about the function of the single phosphosites and their position in the primary, secondary and tertiary structure is lacking. We used a rapid and efficient way to purify yeast RNA Pol ...

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published on 07.12.2007
www.dfg.de
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The Deutsche Forschungsgemeinschaft (German Research Foundation, DFG) announced yesterday the winners of its 2008 Gottfried Wilhelm Leibniz Prize. At its meeting on December 6th 2007, the DFG Joint Committee named CIPSM researcher Dr. Elena Conti as recipient of Germany's most highly endowed research award. Elena will receive 1.25 million euros flexibly over a ...

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