Research Area C - Publications 2018

Nature, volume 556, pages386–390 (2018), doi:10.1038/s41586-018-0029-y
Nature, online article


In the eukaryotic nucleus, DNA is packaged in the form of nucleosomes, each of which comprises about 147 base pairs of DNA wrapped around a histone protein octamer. The position and histone composition of nucleosomes is governed by ATP-dependent chromatin remodellers such as the 15-subunit INO80 complex. INO80 regulates gene expression, DNA repair and replication ...


J. Med. Chem., 2018, 61 (6), pp 2490–2499. DOI: 10.1021/acs.jmedchem.7b01752
J. Med. Chem., online article



Specific targeting of the integrin subtype α5β1 possesses high potential in cancer diagnosis and therapy. Through sequential N-methylation, we successfully converted the biselective α5β1/αvβ6 peptide c(phg-isoDGR-k) into a potent peptidic RGD binding α5β1 subtype selective ligand c(phg-isoDGR-(NMe)k). Nuclear magnetic resonance spectroscopy and molecular modeling ...


ACS Omega, 2018, 3 (2), pp 2428–2436, DOI: 10.1021/acsomega.8b00035
ACS Omega, online article



The epithelial integrin αvβ6 is expressed by many malignant carcinoma cell types, including pancreatic cancer, and thus represents a promising target for radionuclide therapy. The peptide cyclo(FRGDLAFp(NMe)K) was decorated with different chelators (DOTPI, DOTAGA, and DOTA). The Lu(III) complexes of these conjugates exhibited comparable αvβ6 integrin affinities ...


TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry