Research Area C - Publications 2018

Nature, volume 556, pages386–390 (2018), doi:10.1038/s41586-018-0029-y
Nature, online article

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In the eukaryotic nucleus, DNA is packaged in the form of nucleosomes, each of which comprises about 147 base pairs of DNA wrapped around a histone protein octamer. The position and histone composition of nucleosomes is governed by ATP-dependent chromatin remodellers such as the 15-subunit INO80 complex. INO80 regulates gene expression, DNA repair and replication ...

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J. Med. Chem., 2018, 61 (6), pp 2490–2499. DOI: 10.1021/acs.jmedchem.7b01752
J. Med. Chem., online article

 

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Specific targeting of the integrin subtype α5β1 possesses high potential in cancer diagnosis and therapy. Through sequential N-methylation, we successfully converted the biselective α5β1/αvβ6 peptide c(phg-isoDGR-k) into a potent peptidic RGD binding α5β1 subtype selective ligand c(phg-isoDGR-(NMe)k). Nuclear magnetic resonance spectroscopy and molecular modeling ...

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ACS Omega, 2018, 3 (2), pp 2428–2436, DOI: 10.1021/acsomega.8b00035
ACS Omega, online article

 

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The epithelial integrin αvβ6 is expressed by many malignant carcinoma cell types, including pancreatic cancer, and thus represents a promising target for radionuclide therapy. The peptide cyclo(FRGDLAFp(NMe)K) was decorated with different chelators (DOTPI, DOTAGA, and DOTA). The Lu(III) complexes of these conjugates exhibited comparable αvβ6 integrin affinities ...

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