Research Area C - Publications 2019

Cell, 179, 1264–1275, DOI:https://doi.org/10.1016/j.cell.2019.11.001
Cell, online article

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TLR8 is among the highest-expressed pattern-recognition receptors in the human myeloid compartment, yet its mode of action is poorly understood. TLR8 engages two distinct ligand binding sites to sense RNA degradation products, although it remains unclear how these ligands are formed in cellulo in the context of complex RNA molecule sensing. Here, we identified ...

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Journal of Molecular Cell Biology, Volume 11, Issue 10, Pages 845–859, https://doi.org/10.1093/jmcb/mjz086
Journal of Molecular Cell Biology, online article

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Following the discovery of numerous long non-coding RNA (lncRNA) transcripts in the human genome, their important roles in biology and human disease are emerging. Recent progress in experimental methods has enabled the identification of structural features of lncRNAs. However, determining high-resolution structures is challenging as lncRNAs are expected to be ...

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