Non-Hydrolyzable RNA-Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3-Peptidyl tRNA Termini

Angew. Chem. Int. Ed., 2009, 48(42), 4056-4060, doi:10.1002/anie.200900939 published on 24.04.2009
Angew. Chem. Int. Ed., online article

Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA-peptide conjugates that mimic peptidyl-tRNA would be desirable, especially for ribosome structural biology. A flexible solid-phase synthesis strategy now allows efficient access to these highly requested derivatives without restriction on the RNA and peptide sequences.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry