Structural Analysis of Protein Interfaces from 13C Direct-Detected Paramagnetic Relaxation Enhancements

JACS, 2010, DOI: 10.1021/ja1014508,, pp 7285–7287 published on 12.05.2010
JACS, online article

The measurement of 13C directed-detected paramagnetic relaxation enhancements (PREs) on spin-labeled proteins combines the efficacy of PREs for the detection of long-range distance information with the favorable sensitivity and resolution of 13C direct-detected experiments. The 13C PREs provide long-range distance restraints to map binding interfaces in proteins and protein complexes and are especially useful for studies of high-molecular weight perdeuterated molecules.  

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry