MicroRNAs Repress Mainly through mRNA Decay

Angew. Chem. Int. Ed., 2009, 48, 853–855, doi:10.1002/anie.200805127 published on 29.12.2008
Angew. Chem. Int. Ed., online article
Inhibition or degradation? MicroRNAs have been considered primarily as inhibitors of translation, even though degradation of mRNAs also plays a role in their repressive potential. Two research groups have now quantified the extent to which each mechanism contributes to gene regulation by combining mass spectrometry with transcriptome profiling. The surprising conclusion is that translational inhibition plays only a minor role!

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry