Perspectives on NMR in drug discovery: a technique comes of age

Nature Reviews - Drug Disc, 2008, 7, 738-45 published on 26.08.2008
Nature Reviews - Drug discovery, online article

in the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMr) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. in this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry