Redox imaging using genetically encoded redox indicators in zebrafish and mice

Biological Chemistry, 2015, DOI: 10.1515/hsz-2014-0294, Band 396, Heft 5, Seiten 511–522, ISSN (Online) 1437-4315, ISSN (Print) 1431-6730, published on 29.01.2015
Biological Chemistry, online article
Redox signals have emerged as important regulators of cellular physiology and pathology. The advent of redox imaging in vertebrate systems now provides the opportunity to dynamically visualize redox signaling during development and disease. In this review, we summarize recent advances in the generation of genetically encoded redox indicators (GERIs), introduce new redox imaging strategies, and highlight key publications in the field of vertebrate redox imaging. We also discuss the limitations and future potential of in vivo redox imaging in zebrafish and mice.  

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TU München
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Helmholtz München
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MPI of Biochemistry