Differential Regulation of Germline Apoptosis in Response to Meiotic Checkpoint Activation

Genetics ,vol. 198, no. 3, 995-1000, doi: 10.1534/genetics.114.170241

Genetic,online article

In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry