The Cleavage Domain of the Amyloid Precursor Protein Transmembrane Helix Does Not Exhibit Above-Average Backbone Dynamics

ChemBioChem, 2013, DOI: 10.1002/cbic.201300322, Volume 14, Issue 15, pages 1943–1948 published on 11.10.2013
ChemBioChem, online article
The backbone dynamics of the amyloid precursor protein (APP) transmembrane helix was compared to those of other transmembrane domains. In contrast to expectation, no above-average backbone dynamics was found for the APP transmembrane helix; the dynamics thus appears not to be optimized for cleavage.  

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry