Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin

Chem. Commun., 2015, DOI: 10.1039/C5CC00843C, 51, 5334-5336 published on 20.02.2015
Chem. Commun., online article
Polycyclic tetramate macrolactams (PTMs) are a structurally, biomedically and biosynthetically intriguing class of bacterial metabolites. By combining parts of the machineries of different PTM biosynthetic pathways, we demonstrate for the first time the substrate promiscuity of a class of PTM tailoring enzymes, thereby facilitating the (bio)synthesis of butremycin.  

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry