Quantitative chemoproteomic profiling reveals multiple target interactions of spongiolactone derivatives in leukemia cells

Chem. Commun., 2017, 53, 12818--12821, DOI: 10.1039/c7cc04990k
Chem. Commun.online article

The spongiolactones are marine natural products with an unusual rearranged spongiane skeleton and a fused β-lactone ring. These compounds have potential anticancer properties but their mode of action has yet to be explored. Here we employ activity-based protein profiling to identify the targets of a more potent spongiolactone derivative in live cancer cells, and compare these to the targets of a simpler β-lactone. These hits provide the first insights into the covalent mechanism of action of this natural product class.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry