The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity

Chemical Communications, 2011, DOI: 10.1039/C0CC02238A, Communication, 385-387 published on 01.01.2011
Chemical Communications, online article

The preparation of a Syringolin A/Glidobactin A hybrid (SylA–GlbA) consisting of a SylA macrocycle connected to the GlbA side chain and its potent proteasome targeting of all three proteasomal subsites is reported. The influence of the syrbactin macrocycle moiety on subsite selectivity is demonstrated.  

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry