Crystal Structure of a Cisplatin-(1,3-GTG) Cross-Link within DNA Polymerase eta

Angew. Chem. Intl. Ed., 2010, 49 (17), 3077-3080, doi: 10.1002/anie.201000414 published on 23.03.2010
Angewandte Chemie International Edition, online article
Flipped out: The cisplatin-(1,3-GTG) adduct, a strongly cytotoxic DNA lesion generated by the action of cisplatin therapeutics, is partially bypassed by Y-family DNA polymerase . Crystal structure data on this DNA-protein complex explain the partial-bypass process. The central dT unit of the lesion is turned out and blocks the movement of the enzyme along the DNA duplex.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry