Building ProteomeTools based on a complete synthetic human proteome

Nature Methods, volume 14, pages 259–262, doi:10.1038/nmeth.4153
Nature Methods, online article

We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography–tandem mass spectrometry analysis of >330,000 synthetic tryptic peptides representing essentially all canonical human gene products, and we exemplify the utility of these data in several applications. The resource (available at http://www.proteometools.org) will be extended to >1 million peptides, and all data will be shared with the community via ProteomicsDB and ProteomeXchange.

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TU München
MPG
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry