Chemical Probes for Labeling of the Bacterial Glucosaminidase NagZ via the Huisgen Cycloaddition

SYNTHESIS, 2010, DOI: 10.1055/s-0029-1218818, No. 13, pp 2201–2206x published on 15.06.2010
SYNTHESIS, online article
Glycoside hydrolases represent a large class of enzymes that cleave carbohydrate motifs. Since some enzymes play crucial roles in bacterial resistance pathways, we here introduce the synthesis and application of small sugar-based probes to study the function of the glycoside hydrolase NagZ.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry