Parallel Isotope-Based Quantification of Modified tRNA Nucleosides

Angew. Chem. Int. Ed., 2009, 48, 1–4, DOI:10.1002/anie.200902740 published on 11.09.2009
Angew. Chem. Int. Ed., online article

Modifications make a difference: An isotope-based mass spectrometry method allows the facile and quantitative analysis of modified tRNA nucleosides in various types of cells. This method could be capable of distinguishing between individual cell lines as well as between healthy tissue and cancer cells.

TU München
Helmholtz München
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MPI of Biochemistry