Biomimetic synthesis of the IDO inhibitors exiguamine A and B

Nature Chemical Biology, 2008, 47, doi:10.1038/nchembio.107 published on 01.08.2008
Nature Chemical Biology, online article
Biomimetic synthesis is an attempt to assemble natural products along biosynthetic lines without recourse to the full enzymatic machinery of nature. We exemplify this with a total synthesis of exiguamine A and the newly isolated natural product exiguamine B. The most noteworthy feature of this work is an oxidative endgame drawing from the complex chemistry of catecholamines, which allows for ready access to a new class of nanomolar indoleamine-2,3- dioxygenase inhibitors.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry