A Photochromic Agonist of AMPA Receptors

Angewandte Chemie, 2012, DOI: 10.1002/anie.201109265, Volume 51, Issue 23, pages 5748–5751 published on 19.04.2012

Angewandte Chemie. online article

Light switch: A photochromic agonist ATA-3 (see scheme) of AMPA receptors, arguably the most important class of ionotropic glutamate receptors, is shown to be subtype selective, activates the AMPA receptor GluA2 in the dark, and is quickly turned off when irradiated with blue–green light. It can be used to effectively control neuronal activity in the mammalian brain.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry