Research Area D


Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator

Activity, Abundance, and Localization of Quorum Sensing Receptors in Vibrio harveyi

Remodelers tap into nucleosome plasticity

TOM9.2 Is a Calmodulin-Binding Protein Critical for TOM Complex Assembly but Not for Mitochondrial Protein Import in Arabidopsis thaliana

The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

Insulation and wiring specificity of BceR-like response regulators and their target promoters in Bacillus subtilis


Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells

Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration

KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1

The poly(ADP-ribose)-dependent chromatin remodeler Alc1 induces local chromatin relaxation upon DNA damage

Nick Your DNA, Mark Your Chromatin

sNASP and ASF1A function through both competitive and compatible modes of histone binding

Determination of local chromatin composition by CasID

TetraMabs: simultaneous targeting of four oncogenic receptor tyrosine kinases for tumor growth inhibition in heterogeneous tumor cell populations

PionX sites mark the X chromosome for dosage compensation

Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action

Splice variants of the SWR1-type nucleosome remodeling factor Domino have distinct functions during Drosophila melanogaster oogenesis

Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides

Production of Small Non-coding RNAs from the flamenco Locus Is Regulated by the gypsy Retrotransposon of Drosophila melanogaster

p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1

CENPs and Sweet Nucleosomes Face the FACT

Mapping H4K20me3 onto the chromatin landscape of senescent cells indicates a function in control of cell senescence and tumor suppression through preservation of genetic and epigenetic stability

Resolving the α-glycosidic linkage of arginine-rhamnosylated translation elongation factor P triggers generation of the first ArgRha specific antibody

Interleukin-22 is elevated in lavage from patients with lung cancer and other pulmonary diseases

A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination

H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex

Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells

A Dual-Sensing Receptor Confers Robust Cellular Homeostasis

Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression

The Metabolic Impact on Histone Acetylation and Transcription in Ageing

Getting Access to Low-Complexity Domain Modifications

A novel TLR7 agonist reverses NK cell anergy and cures RMA-S lymphoma-bearing mice

Identification and Initial Characterization of Prophages in Vibrio campbellii

Comparison of Intranasal Outer Membrane Vesicles with Cholera Toxin and Injected MF59C.1 as Adjuvants for Malaria Transmission Blocking Antigens AnAPN1 and Pfs48/45

Cross-species analyses unravel the complexity of H3K27me3 and H4K20me3 in the context of neural stem progenitor cells

Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network

Cancer cell-derived IL-1α induces CCL22 and the recruitment of regulatory T cells

High levels of histone H3 acetylation at the CMV promoter are predictive of stable expression in Chinese hamster ovary cells

4D Visualization of replication foci in mammalian cells corresponding to individual replicons

Insights into the DNA-binding mechanism of a LytTR-type transcription regulator

A spherical harmonics intensity model for 3D segmentation and 3D shape analysis of heterochromatin foci

Interaction Analysis of a Two-Component System Using Nanodiscs

The presence of extra chromosomes leads to genomic instability

The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases

A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis

Combinatorial Histone Acetylation Patterns Are Generated by Motif-Specific Reactions

A Quantitative Proteomic Analysis of In Vitro Assembled Chromatin

ε-globin expression is regulated by SUV4-20h1

Heptad-Specific Phosphorylation of RNA Polymerase II CTD

Life span extension by targeting a link between metabolism and histone acetylation in Drosophila


The histone chaperone sNASP binds a conserved peptide motif within the globular core of histone H3 through its TPR repeats

Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery

Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity

CMV promoter mutants with a reduced propensity to productivity loss in CHO cells

Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II

Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling

Stall no more at polyproline stretches with the translation elongation factors EF-P and IF-5A

C-C chemokine receptor type-4 transduction of T cells enhances interaction with dendritic cells, tumor infiltration and therapeutic efficacy of adoptive T cell transfer

Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase

ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence

Chromosomal instability, tolerance of mitotic errors and multidrug resistance are promoted by tetraploidization in human cells

Computational study of remodeling in a nucleosomal array
Active promoters give rise to false positive ‘Phantom Peaks’ in ChIP-seq experiments
DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination
Nanobodies and recombinant binders in cell biology

Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma

A modular open platform for systematic functional studies under physiological conditions

Designing Cell-Type-Specific Genome-wide Experiments

Atrx promotes heterochromatin formation at retrotransposons
Structural and Functional Analysis of the Signal-Transducing Linker in the pH-Responsive One-Component System CadC of Escherichia coli
Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links
DEAD-box helicase DDX27 regulates 3′ end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex
Two distinct modes for propagation of histone PTMs across the cell cycle
The phosphorylation flow of the Vibrio harveyi quorum sensing cascade determines levels of phenotypic heterogeneity in the population
Transcription-Dependent Generation of a Specialized Chromatin Structure at the TCRβ Locus
Phage-mediated Dispersal of Biofilm and Distribution of Bacterial Virulence Genes Is Induced by Quorum Sensing
Arginine-rhamnosylation as new strategy to activate translation elongation factor P
Comparative computational analysis of pluripotency in human and mouse stem cells
Global and Specific Responses of the Histone Acetylome to Systematic Perturbation
Production of Siderophores Increases Resistance to Fusaric Acid in Pseudomonas protegens Pf-5
Emergence of cancer stem cells in hepatocellular carcinoma
Phosphorylation of TET Proteins Is Regulated via O-GlcNAcylation by the O-Linked N-Acetylglucosamine Transferase (OGT)
Ctk1 Function Is Necessary for Full Translation Initiation Activity in Saccharomyces cerevisiae
Polymorphisms in melanoma differentiation-associated gene 5 link protein function to clearance of hepatitis C virus


Parallel Force Assay for Protein-Protein Interactions
Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli
Structural basis of X chromosome DNA recognition by the MSL2 CXC domain during Drosophila dosage compensation
Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control
Structure-guided mutational analysis reveals the functional requirements for product specificity of DOT1 enzymes
Heterochromatin-Mediated Gene Silencing Facilitates the Diversification of Olfactory Neurons
PARP1 and CBP lose their footing in cancer
HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells
A Conserved Proline Triplet in Val-tRNA Synthetase and the Origin of Elongation Factor P
The bacterial translation stress response
UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation
Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site
Specificity, propagation, and memory of pericentric heterochromatin
ACF Takes the Driver’s Seat Hari
Rapid Purification of Recombinant Histones
DNA methylation reader MECP2: cell type- and differentiation stage-specific protein distribution
Concerted Activities of Distinct H4K20 Methyltransferases at DNA Double-Strand Breaks Regulate 53BP1 Nucleation and NHEJ-Directed Repair
Identification of novel Drosophila centromere-associated proteins
A Modular View of the Diversity of Cell-Density-Encoding Schemes in Bacterial Quorum-Sensing Systems
TET-mediated oxidation of methylcytosine causes TDG or NEIL glycosylase dependent gene reactivation
Quiescence-Induced LncRNAs Trigger H4K20 Trimethylation and Transcriptional Silencing
Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells
Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitine-protein ligase UHRF1 and modulates UHRF1 biological functions.
Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production
The Histone-Fold Protein CHRAC14 Influences Chromatin Composition in Response to DNA Damage
The histone variant H2A.Bbd is enriched at sites of DNA synthesis
The structure and substrate specificity of human Cdk12/Cyclin K
Identification of a Novel Nutrient-Sensing Histidine Kinase/Response Regulator Network in Escherichia coli
Visualization of specific DNA sequences in living mouse embryonic stem cells with a programmable fluorescent CRISPR/Cas system
Single Cell Kinetics of Phenotypic Switching in the Arabinose Utilization System of E. coli
Unique features of the transcriptional response to model aneuploidy in human cells
Dynamic karyotype, dynamic proteome: buffering the effects of aneuploidy
Histone glutamine methylation afFACTing rDNA transcription
A CENP-S/X complex assembles at the centromere in S and G2 phases of the human cell cycle
ISWI Remodelling of Physiological Chromatin Fibres Acetylated at Lysine 16 of Histone H4
Self-priming determines high type I IFN production by plasmacytoid dendritic cells
Circadian Control of Fatty Acid Elongation by SIRT1 Protein-mediated Deacetylation of Acetyl-coenzyme A Synthetase 1
New Insights into the Interplay Between the Lysine Transporter LysP and the pH Sensor CadC in Escherichia Coli


The dipeptidylpeptidase-IV inhibitors sitagliptin, vildagliptin and saxagliptin do not impair innate and adaptive immune responses
The macrophage migration inhibitory factor (MIF)-homologue D-dopachrome tautomerase is a therapeutic target in a murine melanoma model
Catch me if you can: How the histone chaperone FACT capitalizes on nucleosome breathing
A Pair of Centromeric Proteins Mediates Reproductive Isolation in Drosophila Species
Targeting and tracing of specific DNA sequences with dTALEs in living cells
Visualization and targeted disruption of protein interactions in living cells
Quantification of Interaction Strengths between Chaperones and Tetratricopeptide Repeat Domain-containing Membrane Proteins
No need for a power stroke in ISWI-mediated nucleosome sliding
CAST-ChIP Maps Cell-Type-Specific Chromatin States in the Drosophila Central Nervous System
Epstein–Barr virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation
4-thiouridine inhibits rRNA synthesis and causes a nucleolar stress response
A New Class of Quorum Quenching Molecules from Staphylococcus Species Affects Communication and Growth of Gram-Negative Bacteria
Nucleosome sliding mechanisms: new twists in a looped history
Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P
Epigenetics of eu- and heterochromatin in inverted and conventional nuclei from mouse retina
The compact view on heterochromatin
The RNA Polymerase II Carboxy-Terminal Domain (CTD) Code
Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse
Emerging roles for RNA polymerase II CTD in Arabidopsis
Dose-dependent regulation of target gene expression and cell proliferation by c-Myc levels
ATP-Dependent roX RNA Remodeling by the Helicase maleless Enables Specific Association of MSL Proteins
Virus-associated activation of innate immunity induces rapid disruption of Peyer’s patches in mice
RNA-Interference Components Are Dispensable for Transcriptional Silencing of the Drosophila Bithorax- Complex
Different chromatin interfaces of the Drosophila dosage compensation complex revealed by high-shear ChIP-seq
Stepwise Evolution of Essential Centromere Function in a Drosophila Neogene
Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function
Cyclin-dependent kinase 9 links RNA Polymerase II transcription to processing of ribosomal RNA
FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis
The recognition and removal of cellular poly(ADP-ribose) signals.
Diurnality and Nocturnality in Primates: An Analysis from the Rod Photoreceptor Nuclei Perspective
Structural basis of histone H2A–H2B recognition by the essential chaperone FACT
Histone H3 Glutathionylation in Proliferating Mammalian Cells Destabilizes Nucleosomal Structure
The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival
Functional ribosome biogenesis is a prerequisite for p53 destabilisation: impact of chemotherapy on nucleolar functions and RNA metabolism.
Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51–Rad52 interaction
Comment on “Drosophila Dosage Compensation Involves Enhanced Pol II Recruitment to Male X-Linked Promoters”
Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin
In vivo live imaging of RNA polymerase II transcription factories in primary cells
TLR Activation Excludes Circulating Naive CD8+ T Cells from Gut-Associated Lymphoid Organs in Mice
The variant histone H2A.V of Drosophila—three roles, two guises
Dissection of cell cycle–dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling
Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease
A family of macrodomain proteins reverses cellular mono-ADP-ribosylation
Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains
H3K56me3 Is a Novel, Conserved Heterochromatic Mark That Largely but Not Completely Overlaps with H3K9me3 in Both Regulation and Localization
Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
LBR and Lamin A/C Sequentially Tether Peripheral Heterochromatin and Inversely Regulate Differentiation
Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity
Circadian acetylome reveals regulation of mitochondrial metabolic pathways
Therapeutic Efficacy of Bifunctional siRNA Combining TGF-β1 Silencing with RIG-I Activation in Pancreatic Cancer
Suv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene
Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation


CTD serine-2 plays a critical role in splicing and termination factor recruitment to RNA polymerase II in vivo
Global DNA Hypomethylation Prevents Consolidation of Differentiation Programs and Allows Reversion to the Embryonic Stem Cell State
Controlling The Mobility Of Oligonucleotides In The Nanochannels Of Mesoporous Silica
Towards a structural understanding of PARP1 activation and related signalling ADP-ribosyl-transferases
Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches
Identification of a Target Gene and Activating Stimulus for the YpdA/YpdB Histidine Kinase/Response Regulator System in Escherichia coli
The ATPase domain of ISWI is an autonomous nucleosome remodeling machine
Direct and Dynamic Detection of HIV-1 in Living Cell
Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks
Autoinducers Act as Biological Timers in Vibrio harveyi
MSL2 Combines Sensor and Effector Functions in Homeostatic Control of the Drosophila Dosage Compensation Machinery
Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors
Histone H2A variants in nucleosomes and chromatin: more or less stable?
Step-Wise Assembly, Maturation and Dynamic Behavior of the Human CENP-P/O/R/Q/U Kinetochore Sub- Complex
Deactivation of the E. coli pH Stress Sensor CadC by Cadaverine
Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
Tyrosine-1 and threonine-4 phosphorylation marks complete the RNA polymerase II CTD phospho-code
Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription
Myb-binding Protein 1a (Mybbp1a) Regulates Levels and Processing of Pre-ribosomal RNA
Nucleosome Remodeler SNF2L Suppresses Cell Proliferation and Migration and Attenuates Wnt Signaling
CTD Tyrosine Phosphorylation Impairs Termination Factor Recruitment to RNA Polymerase II
A unified phylogeny-based nomenclature for histone variants
First insights into the unexplored two-component system YehU/YehT in Escherichia coli
Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function
Versatile Toolbox for High Throughput Biochemical and Functional Studies with Fluorescent Fusion Proteins
EMBO welcomes 3 CIPSM scientists as new members
Cascaded Photoinduced Drug Delivery to Cells from Multifunctional Core–Shell Mesoporous Silica
Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation
Ultra short and progressive 4sU-tagging reveals key characteristics of RNA processing at nucleotide resolution
H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers
ATRX-mediated chromatin association of histone variant macroH2A1 regulates a-globin expression
Structure, function and dynamics of nuclear subcompartments
Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS
Polycomb Associates Genome-wide with a Specific RNA Polymerase II Variant, and Regulates Metabolic Genes in ESCs
Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development
CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin.
Connecting Threads: Epigenetics and Metabolism
Roles of long, non-coding RNA in chromosome-wide transcription regulation: Lessons from two dosage compensation systems
Cytosolic DNA Triggers Mitochondrial Apoptosis via DNA Damage Signaling Proteins Independently of AIM2 and RNA Polymerase III


Histidine kinases and response regulators in networks
Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry
Engineering antibodies and proteins for molecular in vivo imaging
In breast cancer, a high ratio of tumour-infiltrating intraepithelial CD8+ to FoxP3+ cells is characteristic for the medullary subtype
CD103 is a hallmark of tumor-infiltrating regulatory T cells
Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster
De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation
The MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset
Cdc14 phosphatase promotes segregation of telomeres through repression of RNA polymerase II transcription
Suv4-20h Abrogation Enhances Telomere Elongation during Reprogramming and Confers a Higher Tumorigenic Potential to iPS Cells
Regulation of DNA methyltransferase 1 by interactions and modifcations
Proteomic Interrogation of Human Chromatin
Histone hypoacetylation is required to maintain late replication timing of constitutive heterochromatin
Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B
Cooperative DNA and Histone Binding by Uhrf2 Links the Two Major Repressive Epigenetic Pathways
Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36
Stage-Specific Histone Modification Profiles Reveal Global Transitions in the Xenopus Embryonic Epigenome
Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1
Tuning communication fidelity
Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters
Role for hACF1 in the G2/M damage checkpoint
Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain
Systemic Cancer Therapy with a Small Molecule Agonist of Toll-like Receptor 7 Can Be Improved by Circumventing TLR Tolerance
The RNA Helicase Rm62 Cooperates with SU(VAR)3-9 to Re-Silence Active Transcription in Drosophila melanogaster
Twists and turns of DNA methylation
Kirsten Jung's program of emphasis on individuality of bacteria gets DFG funding
Detection and function of an intramolecular disulfide bond in the pH-responsive CadC of Escherichia coli
Functional Nuclear Organization of Transcription and DNA Replication
The C-Terminal Domain of RNA Polymerase II Is Modified by Site-Specific Methylation
H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation
Sequential Establishment of Marks on Soluble Histones H3 and H4
Identification of ArgP and Lrp as Transcriptional Regulators of lysP, the Gene Encoding the Specific Lysine Permease of Escherichia coli
PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms
Global Analysis of the Relationship between JIL-1 Kinase and Transcription
Kirsten Jung Interview about CIPSMs Gender Equality Program
Characterization of PvuRts1I endonuclease as a tool to investigate genomic 5–hydroxymethylcytosine
Histone acetylation controls the inactive X chromosome replication dynamics
H4K20 monomethylation faces the WNT
Transcription modulation chromosome-wide: universal features and principles of dosage compensation in worms and flies
Cortical Constriction During Abscission Involves Helices of ESCRT-III–Dependent Filaments
Interferon Antagonist NSs of La Crosse Virus Triggers a DNA Damage Response-like Degradation of Transcribing RNA Polymerase II
Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1
Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1
Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family
Nuclei of chicken neurons in tissues and three-dimensional cell cultures are organized into distinct radial zones
CpG Blocks Immunosuppression by Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
New Insights into the Signaling Mechanism of the pH-responsive, Membrane-integrated Transcriptional Activator CadC of Escherichia coli
Latest News


The histone methyltransferase Dot1 is required for DNA damage repair and proper development in Dictyostelium
Delivery of Immunostimulatory RNA Oligonucleotides by Gelatin Nanoparticles Triggers an Efficient Antitumoral Response
Every methyl counts – Epigenetic calculus
Fast signals and slow marks: the dynamics of histone modifications
CIPSM sponsors Kirsten Jung's project at the International Genetically Engineered Machine competition (iGEM)
Nucleosome dynamics and epigenetic stability
Developmental role for ACF1-containing nucleosome remodellers in chromatin organisation
Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y
Chemical-genomic dissection of the CTD code
Dosage compensation and the global re-balancing of aneuploid genomes
Efficient Eradication of Subcutaneous but Not of Autochthonous Gastric Tumors by Adoptive T Cell Transfer in an SV40 T Antigen Mouse Model
Sensitive enzymatic quantification of 5-hydroxymethylcytosine in genomic DNA
Form and function of dosage-compensated chromosomes – a chicken-and-egg relationship
A guide to super-resolution fluorescence microscopy
Soft skills turned into hard facts: nucleosome remodelling at developmental switches
The Activation Potential of MOF Is Constrained for Dosage Compensation
Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin
Epigenetic regulation of development by histone lysine methylation
CIPSM Excursion to Bayer Schering Pharma with Kirsten Jung
The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
Novel antibody derivatives for proteome and high-content analysis
Phosphorylation of SU(VAR)3–9 by the Chromosomal Kinase JIL-1
Heterochromatin dysregulation in human diseases
Top-Down de Novo Protein Sequencing of a 13.6 kDa Camelid Single Heavy Chain Antibody by Matrix-Associated Laser Desorption Ionization-Time-of-Flight/Time-of-Flight Mass Spectrometry
Phosphorylation of histone H3T6 by PKCbI controls demethylation at histone H3K4
Replication Stress Interferes with Histone Recycling and Predeposition Marking of New Histones
Chemotherapeutic drugs inhibit ribosome biogenesis at various levels
The complexityofthe‘simple’two-component systemKdpD/KdpE in Escherichia coli
Activation of Melanoma Differentiation-Associated Gene 5 Causes Rapid Involution of the Thymus
Immunostimulatory RNA Blocks Suppression by Regulatory T Cells
The DNA binding CXC domain of MSL2 is required for faithful targeting the Dosage Compensation Complex to the X chromosome
Defects in 18S or 28S rRNA processing activate the p53 pathway
RNA Polymerase II C-terminal Heptarepeat Domain Ser-7 Phosphorylation Is Established in a Mediator-dependent Fashion


The multi-domain protein Np95 connects DNA methylation and histone modification
Modulation of protein properties in living cells using nanobodies
Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression
Superior Protective Immunity against Murine Listeriosis by Combined Vaccination with CpG DNA and Recombinant Salmonella enterica Serovar Typhimurium
Immunostimulatory RNA Oligonucleotides Induce an Effective Antitumoral NK Cell Response through the TLR71
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1beta production
A New Mechanism of Phosphoregulation in Signal Transduction Pathways
RNAPII CTD SER-7 phosphorylation is established in a mediator-dependent fashion
Measurement of replication structures at the nanometer scale using super-resolution light microscopy
CIPSM researcher Prof. Dr. Thomas Cremer is honored by the German Academy of Sciences Leopoldina with the Schleiden Medal
Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells
Bundesministerium supports CIPSM cooperation of CIPSM Investigators Leonhardt and Schotta
Revealing the high-resolution three-dimensional network of chromatin and interchromatin space: A novel electron-microscopic approach to reconstructing nuclear architecture
CIPSM football team rules the cup!
The regulatory interplay between membrane-integrated sensors and transport proteins in bacteria
The dosage compensation complex shapes the conformation of the X chromosome in Drosophila
A Technical Note on Quantum Dots for Multi-Color Fluorescence in situ Hybridization
Induction Kinetics of a Conditional pH Stress Response System in Escherichia coli
Proteome-wide prediction of acetylation substrates
Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon–independent apoptosis in human melanoma cells
Heterogeneity in quorum sensing-regulated bioluminescence of Vibrio harveyi
Changes of higher order chromatin arrangements during major genome activation in bovine preimplantation embryos
Domain swapping reveals that the N-terminal domain of the sensor kinase KdpD in Escherichia coli is important for signaling
CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing
5'-triphosphate RNA requires base-paired structures to activate antiviral signaling via RIG-I
DNA Methylation-Mediated Epigenetic Control
Chromosome shattering: a mitotic catastrophe due to chromosome condensation failure
Establishment of Histone Modifications after Chromatin Assembly
MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos
MBD4 and MLH1 are required for apoptotic induction in xDNMT1-depleted embryos
The HP1a–CAF1–SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin
TFIIH Kinase Places Bivalent Marks on the Carboxy-Terminal Domain of RNA Polymerase II
Stimulation of the potassium sensor KdpD kinase activity by interaction with the phosphotransferase protein IIANtr in Escherichia coli
Morphological and immunocytochemical characteristics indicate the yield of early progenitors and represent a quality control for human mesenchymal stem cell culturing
Drosophila ISWI Regulates the Association of Histone H1 With Interphase Chromosomes in Vivo
Nuclear Architecture of Rod Photoreceptor Cells Adapts to Vision in Mammalian Evolution
Drosophila HP1c Is Regulated by an Auto-Regulatory Feedback Loop through Its Binding Partner Woc
Synergy between CD26/DPP-IV Inhibition and G-CSF Improves Cardiac Function after Acute Myocardial Infarction
Active promoters and insulators are marked by the centrosomal protein 190
How are signals transduced across the cytoplasmic membrane? Transport proteins as transmitter of information
Spatiotemporal Dynamics of Regulatory Protein Recruitment at DNA Damage Sites
Dimerization of DNA Methyltransferase 1 Is Mediated by Its Regulatory Domain
Backbone Structure of Transmembrane Domain IX of the Naþ/Proline Transporter PutP of Escherichia coli
A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding
Monomethylation of Lysine 20 on Histone H4 Facilitates Chromatin Maturation


The Chromosomal High-Affinity Binding Sites for the Drosophila Dosage Compensation Complex
The Universal Stress Protein UspC Scaffolds the KdpD/KdpE Signaling Cascade of Escherichia coli under Salt Stress
Recruitment of RNA polymerase II cofactor PC4
5´-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Short-term activation induces multifunctional dendritic cells that generate potent antitumor T-cell responses in vivo
Discontinuous movement of mRNP particles in nucleoplasmic regions devoid of chromatin
Identifying specific protein interaction partners using quantitative mass spectrometry and bead proteomes
Camelid immunoglobulins and nanobody technology
Combined Use of RNAi and Quantitative Proteomics to Study Gene Function in Drosophila
PR-SET7 and SUV4-20H regulate H4 lysine-20 methylation at imprinting control regions in the mouse
Function of Transmembrane Domain IX in the Na+/Proline Transporter PutP
A fluorescent two-hybrid (F2H) assay for direct visualization of protein interactions in living cells
Uncoupling the replication machinery
Targeting CpG Oligonucleotides to the Lymph Node by Nanoparticles Elicits Efficient Antitumoral Immunity
Nuclear transit of the RNA-binding protein She2 is required for translational control of localized ASH1 mRNA
Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse
The PHD Domain of Np95 (mUHRF1) Is Involved in Large-Scale Reorganization of Pericentromeric Heterochromatin
Photorhabdus luminescens genes induced upon insect infection
Simultaneous Transport of Different Localized mRNA Species Revealed by Live-Cell Imaging
Molecular evolution of the RNA polymerase II CTD
Generation and Characterization of a Rat Monoclonal Antibody Specific for Multiple Red Fluorescent Proteins
Simple generation of site-directed point mutations in the Escherichia coli chromosome using Red®/ET® Recombination
DNA vaccination efficiently induces antibodies to Nogo-A and does not exacerbate experimental autoimmune encephalomyelitis
ATP-dependent chromatosome remodeling
CIPSM-Researcher Heinrich Leonhardt wins Binder-Innovation Award 2008
DNA sequence and the organization of chromosomal domains
The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing
Fine Mapping of Posttranslational Modifications of the Linker Histone H1 from Drosophila melanogaster
Chromatin proteomics and epigenetic regulatory circuits


Structure-function analysis of the RNA helicase maleless
Seven Ups the Code
Transcribing RNA Polymerase II Is Phosphorylated at CTD Residue Serine-7
Serine-7 of the RNA Polymerase II CTD Is Specifically Required for snRNA Gene Expression
Structure–function analysis of the RNA polymerase cleft loops elucidates initial transcription, DNA unwinding and RNA displacement
Probing Intranuclear Environments at the Single-Molecule Level
NC2 mobilizes TBP on core promoter TATA boxes
A mutagenesis strategy combining systematic alanine scanning with larger mutations to study protein interactions
Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells
A Versatile Nanotrap for Biochemical and Functional Studies with Fluorescent Fusion Proteins
Maintenance of imprinting and nuclear architecture in cycling cells
TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry