Getting Access to Low-Complexity Domain Modifications

Trends in Biochemical Sciences, DOI:
Trends in Biochemical Sciences, online article

Low-complexity (LC) domains regulate the aggregation and phase transition of proteins in a modification-dependent manner. The study of LC domain modifications has now become feasible, as shown by genetic variants of the carboxy-terminal domain (CTD) of RNA Polymerase II (Pol II) that provide access to the type and position of modifications of a LC domain by mass spectrometry (MS).

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry