Research Area D - Publications 2018

Open Biol., 8: 180023, http://dx.doi.org/10.1098/rsob.180023
Open Biol., online article

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Every living cell possesses numerous transmembrane signalling systems that receive chemical and physical stimuli from the environment and transduce this information into an intracellular signal that triggers some form of cellular response. As unicellular organisms, bacteria require these systems for survival in rapidly changing environments. The receptors ...

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Molecular Metabolism, Volume 9, March 2018, Pages 57-68, https://doi.org/10.1016/j.molmet.2018.01.011
Molecular Metabolism, online article

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Objective: Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor (TF) PDX1 leads to pancreatic agenesis, whereas heterozygous mutations can cause Maturity-Onset Diabetes of the Young 4 (MODY4). Although the function of Pdx1 is well studied in pre-clinical models during insulin-producing β-cell development and homeostasis, ...

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Mitochondrion, https://doi.org/10.1016/j.mito.2018.01.005
Mitochondrion, online ablage

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Mitochondrial localized proteins are mostly synthesized in the cytosol and translocated across the outer mitochondrial membrane via the translocase of the outer membrane (TOM) complex. Although the channel protein is conserved among eukaryotes, the receptor proteins are more divergent and show features specific to the plant lineage. OM64, which is a paralogue of ...

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Nature Communications, 9, Article number: 299, doi:10.1038/s41467-017-02582-1
Nature Communications, online article

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The ubiquitously expressed RNA-binding proteins Roquin-1 and Roquin-2 are essential for appropriate immune cell function and postnatal survival of mice. Roquin proteins repress target mRNAs by recognizing secondary structures in their 3′-UTRs and by inducing mRNA decay. However, it is unknown if other cellular proteins contribute to target control. To identify ...

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eLife 2018;7:e32010 doi: 10.7554/eLife.32010
eLife, online article

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The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
 

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