Research Area D - Publications 2018

Nature Communications, 9, Article number: 299, doi:10.1038/s41467-017-02582-1
Nature Communications, online article

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The ubiquitously expressed RNA-binding proteins Roquin-1 and Roquin-2 are essential for appropriate immune cell function and postnatal survival of mice. Roquin proteins repress target mRNAs by recognizing secondary structures in their 3′-UTRs and by inducing mRNA decay. However, it is unknown if other cellular proteins contribute to target control. To identify ...

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eLife 2018;7:e32010 doi: 10.7554/eLife.32010
eLife, online article

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The transcription factor c-Myc amplifies the transcription of many growth-related genes in cancer cells, but its role as an oncogene is not fully understood.
 

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