Research Area D - Publications 2021
12-Mar-2021
Sci Rep 11, 5838 (2021). https://doi.org/10.1038/s41598-021-84708-6
Scientific Reports, online article

Chemotherapy resistance is the main impediment in the treatment of acute myeloid leukaemia (AML). Despite rapid advances, the various mechanisms inducing resistance development remain to be defined in detail. Here we report that loss-of-function mutations (LOF) in the histone methyltransferase EZH2 have the potential to confer resistance against the ...
11-Mar-2021
J. Cell Biol. 2021 Vol. 220 No. 5 e202008030, https://doi.org/10.1083/jcb.202008030
J. Cell Biol., online article

RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair, and it undergoes reversible liquid–liquid phase separation (LLPS) in vitro. Here, we demonstrate that FUS-dependent LLPS is necessary for the initiation of the DDR. Using laser microirradiation in ...