Research Area D - Publications 2019

Angewandte Chemie International Edition, https://doi.org/10.1002/anie.201814715
Angewandte Chemie International Edition, online article

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We describe a new technique in protein synthesis that extends the existing repertoire of methods for protein modification: A chemoselective reaction that induces reactivity for a subsequent bioconjugation. Hereby, an azide building block reacts first with an ethynylphosphonite via the Staudinger‐phosphonite reaction (SPhR) to an ethynylphosphonamidate. The ...

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Journal of Bacteriology, Volume 201, Issue 3, e00610-18, https://doi.org/10.1128/JB.00610-18
Journal of Bacteriology, online article

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Escherichia coli and many other bacterial species can enter into a viable but nonculturable (VBNC) state, which is a survival strategy adopted by cells exposed to adverse environmental conditions. Pyruvate is known to be one factor that promotes resuscitation of VBNC cells. Here we studied the role of a pyruvate-sensing network, composed of the histidine ...

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Nucleic Acids Research, 2019, 1, doi: 10.1093/nar/gky1320
Nucleic Acids Research, online article

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Bacteria use quorum sensing to monitor cell density and coordinate group behaviours. In Vibrio cholerae, the causative agent of the diarrheal disease cholera, quorum sensing is connected to virulence gene expression via the two autoinducer molecules, AI-2 and CAI-1. Both autoinducers share one signal transduction pathway to control the production of AphA, a key ...

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COMMUNICATIONS BIOLOGY, (2019) 2:4, https://doi.org/10.1038/s42003-018-0248-7
COMMUNICATIONS BIOLOGY, online article

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All living cells have a large number of proteins that are anchored with one transmembrane helix in the cytoplasmic membrane. Almost nothing is known about their spatiotemporal organization in whole cells. Here we report on the localization and dynamics of one representative, the pH sensor and transcriptional regulator CadC in Escherichia coli. Fluorophore-tagged ...

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