Unique features of the transcriptional response to model aneuploidy in human cells

BMC Genomics, 2014, doi:10.1186/1471-2164-15-139, 15:139 published on 18.02.2014
BMC Genomics, online article
Aneuploidy, a karyotype deviating from multiples of a haploid chromosome set, affects the physiology of eukaryotes. In humans, aneuploidy is linked to pathological defects such as developmental abnormalities, mental retardation or cancer, but the underlying mechanisms remain elusive. There are many different types and origins of aneuploidy, but whether there is a uniform cellular response to aneuploidy in human cells has not been addressed so far.  

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry