ATM, MacroH2A.1, and SASP: The Checks and Balances of Cellular Senescence
Molecular Cell, Volume 59, Issue 5, p713–715, DOI: http://dx.doi.org/10.1016/j.molcel.2015.08.010
Oncogene activation is usually not enough to induce cancer, but causes cells to arrest proliferation, alter chromatin structure, and increase protein secretion. In this issue of Molecular Cell, Chen et al. (2015) implicate the histone variant macroH2A.1 in the regulation of senescence.