Fusion of Bacterial Flagellin to a Dendritic Cell-Targeting αCD40 Antibody Construct Coupled With Viral or Leukemia-Specific Antigens Enhances Dendritic Cell Maturation and Activates Peptide-Responsive T Cells
Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma
TLR8 Is a Sensor of RNase T2 Degradation Products
Challenges and perspectives for structural biology of lncRNAs—the example of the Xist lncRNA A-repeats
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells
The Antibody Light-Chain Linker Regulates Domain Orientation and Amyloidogenicity
A single residue switch reveals principles of antibody domain integrity
Targeting TRAF6 E3 ligase activity with a small molecule inhibitor combats autoimmunity
Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1
Protons as Versatile Reporters in Solid-State NMR Spectroscopy
A switch point in the molecular chaperone Hsp90 responding to client interaction
Von einer Helix zu einem kleinen Ring: Metadynamik‐inspirierte, selektive Liganden für αvβ6‐Integrin
Structural basis for ATP-dependent chromatin remodelling by the INO80 complex
In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors
Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1
Ultrashort Broadband Cooperative Pulses for Multidimensional Biomolecular NMR Experiments
N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent
Therapeutic Radiopharmaceuticals Targeting Integrin αvβ6
Dynamics and Interactions of a 29 kDa Human Enzyme Studied by Solid-State NMR
A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer
Towards the cell-instructive bactericidal substrate: exploring the combination of nanotopographical features and integrin selective synthetic ligands
Microsecond Timescale Protein Dynamics: a Combined Solid‐State NMR Approach
Molecular basis for asymmetry sensing of siRNAs by the Drosophila Loqs-PD/Dcr-2 complex in RNA interference
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders
Structural insights into the interaction of the nuclear exosome helicase Mtr4 with the preribosomal protein Nop53
Exploring the Role of RGD-Recognizing Integrins in Cancer
Improving oral bioavailability of cyclic peptides by N-methylation
Highly Ordered Gold Nanopatterned Indium Tin Oxide Electrodes for Simultaneous Optical and Electrochemical Probing Cell Interactions
A chemical compound inhibiting the Aha1-Hsp90 chaperone complex
Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations
Expression and purification of a difficult sarcomeric protein: Telethonin
Effects of Fluorophore Attachment on Protein Conformation and Dynamics Studied by spFRET and NMR Spectroscopy
MAK33 antibody light chain amyloid fibrils are similar to oligomeric precursors
Structural Insights into Selective Ligand–Receptor Interactions Leading to Receptor Inactivation Utilizing Selective Melanocortin 3 Receptor Antagonists
RNA structure refinement using NMR solvent accessibility data
Segmental, Domain-Selective Perdeuteration and Small-Angle Neutron Scattering for Structural Analysis of Multi-Domain Proteins
Inhibitors of glycosomal protein import provide new leads against trypanosomiasis
Fibronectin promotes directional persistence in fibroblast migration through interactions with both its cell-binding and heparin-binding domains
Microsecond Time Scale Proton Rotating-Frame Relaxation under Magic Angle Spinning
Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator
Discrimination of Cytosolic Self and Non-Self RNA by RIG-I-like Receptors
Protein conformational dynamics studied by 15N and 1H R1ρ relaxation dispersion: Application to wild-type and G53A ubiquitin crystals
Non-equilibrium hydrogen exchange for determination of H-bond strength and water accessibility in solid proteins
Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites
Integrated structural biology to unravel molecular mechanisms of protein-RNA recognition
Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19
Focal adhesion stabilization by enhanced integrin-cRGD binding affinity
The glia of the adult Drosophila nervous system
Epigallocatechin-3-gallate preferentially induces aggregation of amyloidogenic immunoglobulin light chains
A two-component adhesive: Tau fibrils arise from a combination of a well-defined motif and conformationally flexible interactions
Dynamic analysis of the mesenchymal-epithelial transition of blood-brain barrier forming glia in Drosophila
Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex
A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins
The NLRP3 Inflammasome Renders Cell Death Pro-inflammatory
Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions
In-vivo PET imaging of the "cancer integrin" αvβ6 using gallium-68 labelled cyclic RGD nonapeptides
Structural basis for ArfA–RF2-mediated translation termination on mRNAs lacking stop codons
Deciphering the Translation Initiation Factor 5A Modification Pathway in Halophilic Archaea
Structural basis for the recognition of spliceosomal SmN/B/B’ proteins by the RBM5 OCRE domain in splicing regulation
Recognition of the 3′ splice site RNA by the U2AF heterodimer involves a dynamic population shift
Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing
cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites
Importance of cycle timing for the function of the molecular chaperone Hsp90
Structural biology of the import pathways of peroxisomal matrix proteins
DNA annealing by Redβ is insufficient for homologous recombination and the additional requirements involve intra- and inter-molecular interactions
Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions
Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex
Bacterial Protein Synthesis as a Target for Antibiotic Inhibition
A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest
Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome
Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length
Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding
Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1
Solution structure and binding specificity of the p63 DNA binding domain
RIG-I-Like Receptors: One STrEP Forward
The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis
Invited review: Architectures and mechanisms of ATP binding cassette proteins
Variation of Specific Activities of Ga-68-Aquibeprin and Ga-68-Avebetrin Enables Selective PET-Imaging of Different Expression Levels of Integrins α5β1 and αvβ3
αvβ3- or α5β1-Integrin-Selective Peptidomimetics for Surface Coating
The ABC of Ribosome-Related Antibiotic Resistance
Recognition of Endogenous Nucleic Acids by the Innate Immune System
Roquin recognizes a non-canonical hexaloop structure in the 3′-UTR of Ox40
Immobilization of soluble protein complexes in MAS solid-state NMR: Sedimentation versus viscosity
Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells
Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation
Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation
Sulindac Sulfide Induces the Formation of Large Oligomeric Aggregates of the Alzheimer’s Disease Amyloid-β Peptide Which Exhibit Reduced Neurotoxicity
Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50
Translation regulation via nascent polypeptide-mediated ribosome stalling
A Stable Mutant Predisposes Antibody Domains to Amyloid Formation through Specific Non-Native Interactions
Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress
Structure of the mammalian antimicrobial peptide Bac7(1–16) bound within the exit tunnel of a bacterial ribosome
Structural basis of RNA recognition and dimerization by the STAR proteins T-STAR and Sam68
Improved Accuracy from Joint X-ray and NMR Refinement of a Protein–RNA Complex Structure
Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction
RNA recognition by Roquin in posttranscriptional gene regulation
Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome
Stable Peptides Instead of Stapled Peptides: Highly Potent αvβ6-Selective Integrin Ligands
Small Cause, Great Impact: Modification of the Guanidine Group in the RGD Motif Controls Integrin Subtype Selectivity
Caveolin-1-negative head and neck squamous cell carcinoma primary tumors display increased epithelial to mesenchymal transition and prometastatic properties
Restoring Resolution in Biological Solid-State NMR under Conditions of Off-Magic-Angle Spinning
ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA
Structural basis for cpSRP43 chromodomain selectivity and dynamics in Alb3 insertase interaction
Blast from the Past: Reassessing ForgottenTranslation Inhibitors, Antibiotic Selectivity, and ResistanceMechanisms to Aid Drug Development
Blast from the Past: Reassessing Forgotten Translation Inhibitors, Antibiotic Selectivity, and Resistance Mechanisms to Aid Drug Development
The Antibody Light-Chain Linker Is Important for Domain Stability and Amyloid Formation
Structure of the RNA Helicase MLE Reveals the Molecular Mechanisms for Uridine Specificity and RNA-ATP Coupling
Stall no more at polyproline stretches with the translation elongation factors EF-P and IF-5A
Hsp90·Cdc37 Complexes with Protein Kinases Form Cooperatively with Multiple Distinct Interaction Sites
Structure of a Human 4E-T/DDX6/CNOT1 Complex Reveals the Different Interplay of DDX6-Binding Proteins with the CCR4-NOT Complex
In vivo biokinetic and metabolic characterization of the 68Ga-labelled α5β1-selective peptidomimetic FR366
Bioactive compounds immobilized on Ti and TiNbHf: AFM-basedinvestigations of biofunctionalization efficiency and cell adhesion
Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma
The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client
Structural biology of the import pathways of peroxisomalmatrix proteins
Towards the molecular mechanism of the integration of peroxisomal membrane proteins
Structural Mechanism of the Interaction of Alzheimer Disease A Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac Sulfide
Entropic Contribution of Elongation Factor P to Proline Positioning at the Catalytic Center of the Ribosome
Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions
cis-Peptide Bonds: A Key for Intestinal Permeability of Peptides?
Efficient segmental isotope labeling of multi-domain proteins using Sortase A
Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1
Minimal Synthetic Cells to Study Integrin-Mediated Adhesion
RNA degradation paths in a 12-subunit nuclear exosome complex
Systematic Backbone Conformational Constraints on a Cyclic Melanotropin Ligand Leads to Highly Selective Ligands for Multiple Melanocortin Receptors
Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3-dATP
Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3
A Crystallin Fold in the Interleukin-4-inducing Principle of Schistosoma mansoni Eggs (IPSE/α-1) Mediates IgE Binding for Antigen-independent Basophil Activation
Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases
Segregation Versus Colocalization: Orthogonally Functionalized Binary Micropatterned Substrates Regulate the Molecular Distribution in Focal Adhesions
Architecture of the Ubiquitylation Module of the Yeast Ccr4-Not Complex
Hsp90 regulates the dynamics of its cochaperone Sti1 and the transfer of Hsp70 between modules
Structural Basis for Dodecameric Assembly States and Conformational Plasticity of the Full-Length AAA+ ATPases Rvb1·Rvb2
Annotation of genomics data using bidirectional hidden Markov models unveils variations in Pol II transcription cycle
Drug Sensing by the Ribosome Induces Translational Arrest via Active Site Perturbation
Receptor-Bound Conformation of Cilengitide Better Represented by Its Solution-State Structure than the Solid-State Structure
A Residue-specific Shift in Stability and Amyloidogenicity of Antibody Variable Domains
Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1
Recruitment of TREX to the Transcription Machinery by Its Direct Binding to the Phospho-CTD of RNA Polymerase II
Amythiamicin D and Related Thiopeptides as Inhibitors of the Bacterial Elongation Factor EF-Tu: Modification of the Amino Acid at Carbon Atom C2 of Ring C Dramatically Influences Activity
On the use of the antibiotic chloramphenicol to target polypeptide chain mimics to the ribosomal exit tunnel
Unveiling the Long-Held Secrets of the 26S Proteasome
Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P
A Cyclen-Based Tetraphosphinate Chelator for the Preparation of Radiolabeled Tetrameric Bioconjugates
Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesis
Translational repression of thymidylate synthase by targeting its mRNA
Radiolabelled RGD peptides for imaging and therapy
Structural basis of highly conserved ribosome recycling in eukaryotes and archaea
Structure and DNA-binding activity of the Pyrococcus furiosus SMC protein hinge domain
Mechanism of replication blocking and bypass of Y-family polymerase Eta by bulky acetylaminofluorene DNA adducts
Optimized Measurement Temperature Gives Access to the Solution Structure of a 49 kDa Homohexameric Beta - Propeller
Polymeric Substrates with Tunable Elasticity and Nanoscopically Controlled Biomolecule Presentation
Uniform transitions of the general RNA polymerase II transcription complex
Structure of an atypical Tudor domain in the Drosophila Polycomblike protein
Improvement of drug-like properties of peptides: the somatostatin paradigm
Structural Basis for Homodimerization of the Src-associated during Mitosis, 68-kDa Protein (Sam68) Qua1 Domain
The archaeo-eukaryotic primase of plasmid pRN1 requires a helix bundle domain for faithful primer synthesis
Interplay between the Ribosomal Tunnel, Nascent Chain, and Macrolides Influences Drug Inhibition
Structural Analysis of Protein Interfaces from 13C Direct-Detected Paramagnetic Relaxation Enhancements
Structure and RNA recognition by the snRNA and snoRNA transport factor PHAX
Quantitative analysis of processive RNA degradation by the archaeal RNA exosome
Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif
Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins
Preparation and topology of the Mediator middle module
Enhanced SnapShot: Antibiotic Inhibition of Protein Synthesis II
The torpedo nuclease Rat1 is insufficient to terminate RNA polymerase II in vitro
Molecular basis of transcriptional mutagenesis at 8-oxoguanine
The Final Step of Hygromycin A Biosynthesis, Oxidation of C-5''-Dihydrohygromycin A, Is Linked to a Putative Proton Gradient-Dependent Efflux
Nano positioning system reveals the course of upstream and nontemplate DNA within the RNA polymerase II elongation complex
Adhesion Dance with Raver
Breaking the Dogma of the Metal-Coordinating Carboxylate Group in Integrin Ligands: Introducing Hydroxamic Acids to the MIDAS To Tune Potency and Selectivity
A movie of the RNA polymerase nucleotide addition cycle
Structure and in Vivo Requirement of the Yeast Spt6 SH2 Domain
Non-Hydrolyzable RNA-Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3-Peptidyl tRNA Termini
Sequence context-specific profiles for homology searching
Structure and Ligand Binding of the Extended Tudor Domain of D. melanogaster Tudor-SN
Structure–function studies of the RNA polymerase II elongation complex
Time-Resolved Binding of Azithromycin to Escherichia coli Ribosomes
A Distinct Mode of Interaction of a Novel Ketolide Antibiotic That Displays Enhanced Antimicrobial Activity
The archaeal RNA polymerase subunit P and the eukaryotic polymerase subunit Rpb12 are interchangeable in vivo and in vitro
Perspectives on NMR in drug discovery: a technique comes of age
Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation
Rational Design of Highly Active and Selective Ligands for the alpha-5-beta-1 Integrin Receptor
The Role of 23S Ribosomal RNA Residue A2451 in Peptide Bond Synthesis Revealed by Atomic Mutagenesis
The sweetest candy for the virus
Assessment of αvβ3 Integrin Expression after Myocarcdial Infarction by Positron Emission Tomography
Cryo-EM study of the spinach chloroplast ribosome reveals the structural and functional roles of plastid-specific ribosomal proteins
Molecular basis of RNA-dependent RNA polymerase II activity
Drosophilia microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1
piRNAs-the ancient hunters of genome invaders
Structural basis for DNA duplex sepration by a superfamily-2 helicase
CPD Damage Recognition by Transcribing RNA Polymerase II
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