Enhanced SnapShot: Antibiotic Inhibition of Protein Synthesis II
Cell, 2009, 139(1), pp. 212 - 212.e1, doi:10.1016/j.cell.2009.08.009 published on 02.10.2009
Cell, online article
The translational apparatus is one of the major targets for antibiotics in the bacterial cell. Antibiotics predominantly interact with the functional centers of the ribosome, namely the messenger RNA (mRNA)-transfer RNA (tRNA) decoding region on the 30S subunit, the peptidyltransferase center on the 50S subunit, or the ribosomal exit tunnel through which the nascent polypeptide chain passes during translation. Protein synthesis can be divided into three phases: initiation, elongation, and termination/recycling.