Research Area C - Publications 2020

Frontiers in Immunology, 11, 602802, https://doi.org/10.3389/fimmu.2020.602802
Frontiers in Immunology, online article

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Conventional dendritic cell (DC) vaccine strategies, in which DCs are loaded with antigens ex vivo, suffer biological issues such as impaired DC migration capacity and laborious GMP production procedures. In a promising alternative, antigens are targeted to DC-associated endocytic receptors in vivo with antibody–antigen conjugates co-administered with toll-like ...

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Cell Rep., [online ahead of print] , DOI:https://doi.org/10.1016/j.celrep.2020.107522
Cell Rep., online article

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Tumor cells orchestrate their microenvironment. Here, we provide biochemical, structural, functional, and clinical evidence that Cathepsin S (CTSS) alterations induce a tumor-promoting immune microenvironment in follicular lymphoma (FL). We found CTSS mutations at Y132 in 6% of FL (19/305). Another 13% (37/286) had CTSS amplification, which was associated with ...

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