Research Area F - Publications 2019

Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans

01-Oct-2019

Anita Wagner, Olga Hofmeister, Stephane G. Rolland, Andreas Maiser, Koit Aasumets, Sabine Schmitt, Kenji Schorpp, Annette Feuchtinger, Kamyar Hadian, Sabine Schneider, Hans Zischka, Heinrich Leonhardt, Barbara Conradt, Joachim M. Gerhold, Alexander Wolf

Journal of Cell Science; 2019; 132: jcs223891; doi: 10.1242/jcs.223891
Journal of Cell Science, online article

schneider_leonhardt_conradt_2019_wagner_550.100x0.jpg

The Fe(II) and 2-oxoglutarate-dependent oxygenase Alkb homologue 1 (Alkbh1) has been shown to act on a wide range of substrates, like DNA, tRNA and histones. Thereby different enzymatic activities have been identified including, among others, demethylation of N3-methylcytosine (m3C) in RNA- and single-stranded DNA oligonucleotides, demethylation of ...

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