Remodelers tap into nucleosome plasticity
Nature Structural & Molecular Biology, 24, 341–343, doi:10.1038/nsmb.3394
Nature Structural & Molecular Biology, online article
Chromatin-remodeling enzymes perform the formidable task of reorganizing the structure of a stable macromolecular assembly, the nucleosome. Recently published work demonstrates that the SNF2H chromatin remodeler distorts the histone octamer structure upon binding to the nucleosome, then taps into this induced plasticity to productively achieve nucleosome sliding.