Research Area D - Publications 2021

EMBO J (2021), e102277, https://doi.org/10.15252/embj.2019102277
EMBO J, online article

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The ongoing outbreak of severe acute respiratory syndrome (SARS) coronavirus 2 (SARS‐CoV‐2) demonstrates the continuous threat of emerging coronaviruses (CoVs) to public health. SARS‐CoV‐2 and SARS‐CoV share an otherwise non‐conserved part of non‐structural protein 3 (Nsp3), therefore named as “SARS‐unique domain” (SUD). We previously found a yeast‐2‐hybrid ...

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Sci Rep 11, 5838 (2021). https://doi.org/10.1038/s41598-021-84708-6
Scientific Reports, online article

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Chemotherapy resistance is the main impediment in the treatment of acute myeloid leukaemia (AML). Despite rapid advances, the various mechanisms inducing resistance development remain to be defined in detail. Here we report that loss-of-function mutations (LOF) in the histone methyltransferase EZH2 have the potential to confer resistance against the ...

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J. Cell Biol. 2021 Vol. 220 No. 5 e202008030, https://doi.org/10.1083/jcb.202008030
J. Cell Biol., online article

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RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair, and it undergoes reversible liquid–liquid phase separation (LLPS) in vitro. Here, we demonstrate that FUS-dependent LLPS is necessary for the initiation of the DDR. Using laser microirradiation in ...

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