Functional ribosome biogenesis is a prerequisite for p53 destabilisation: impact of chemotherapy on nucleolar functions and RNA metabolism.

Biol. Chem., 2013, DOI 10.1515/hsz-2013-0153, published on 01.05.2013
Biol. Chem., online article
The production and processing of ribosomal RNA is a complex and well-coordinated nucleolar process for ribosome biogenesis. Progress in understanding nucleolar structure and function has lead to the unexpected discovery of the nucleolus as highly sensitive sensor of cellular stress and important regulator of the tumour suppressor p53. Inhibition of ribosomal RNA metabolism has been shown to activate a signalling pathway for p53 induction. This review elucidates the potential of classical and recently developed chemotherapeutic drugs to stabilise p53 by inhibiting nucleolar functions.  

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