Dosage compensation and the global re-balancing of aneuploid genomes
Genome Biology, 2010, doi:10.1186/gb-2010-11-8-216, published on 26.08.2010
Genome Biology, online article
Diploid genomes are exquisitely balanced systems of gene expression. The dosage-compensation systems that evolved along with monosomic sex chromosomes exemplify the intricacies of compensating for differences in gene copy number by transcriptional regulation.