Actin: its cumbersome pilgrimage through cellular compartments

Histochemistry and Cell Biology, 2008, DOI 10.1007/s00418-008-0430-y, published on 26.04.2008
Histochemistry; online article
In this article, we follow the history of one of the most abundant, most intensely studied proteins of the eukaryotic cells: actin. We report on hallmarks of its discovery, its structural and functional characterization and localization over time, and point to present days’ knowledge on its position as a member of a large family. We focus on the rather puzzling number of diverse functions as proposed for actin as a dual compartment protein. Finally, we venture on some speculations as to its origin.

TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry