Switching first contact: photocontrol of E. coli adhesion to human cells

Chem. Commun.,52, 1254-1257, DOI: 10.1039/C5CC08884D

Chem. Commun., online article

We have shown previously that carbohydrate-specific bacterial adhesion to a non-physiological surface can be photocontrolled by reversible E/Z isomerisation using azobenzene-functionalised sugars. Here, this approach is applied to the surface of human cells. We show not only that bacterial adhesion to the azobenzene glycoside-modified cell surface is higher in the E than in the Z state, but add data about the specific modulation of the effect.


TU München
Helmholtz München
MPI of Neurobiology
MPI of Biochemistry