Research Area A - Publications 2018

bioRxiv, doi: https://doi.org/10.1101/265405
bioRxiv, online article

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Expansion microscopy evolved as an interesting alternative in the field of super-resolution microscopy by physically expanding the target sample to increase its size by a multiple and to subsequently image the sample by conventional fluorescence microcopy. But the quantitative determination of the expansion factor remains challenging, since microscopic ...

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Nano Lett.,  DOI: 10.1021/acs.nanolett.7b05354
Nano Lett., online article

 

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We explore the potential of DNA nanotechnology for developing novel optical voltage sensing nano-devices that convert a local change of electric potential into optical signals. As a proof-of-concept of the sensing mechanism, we assembled voltage responsive DNA origami structures labelled with a single pair of FRET dyes. The DNA structures were reversibly ...

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ChemBioChem, DOI: 10.1002/cbic.201700696
ChemBioChem, online article

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Human cells are complex entities in which molecular recognition and selection are critical for cellular processes often driven by structural changes and dynamic interactions. Biomolecules appear in different chemical states and modifications like phosphorylation affect their function. Hence, using proteins in their chemically native state in biochemical and ...

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Science, Vol. 359, Issue 6373, pp. 296-301, DOI: 10.1126/science.aao4284
Science, online article

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The use of dynamic, self-assembled DNA nanostructures in the context of nanorobotics requires fast and reliable actuation mechanisms. We therefore created a 55-nanometer–by–55-nanometer DNA-based molecular platform with an integrated robotic arm of length 25 nanometers, which can be extended to more than 400 nanometers and actuated with externally applied ...

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Nature Chemistry, doi:10.1038/nchem.2916
Nature Chemitry, online article

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The entatic state denotes a distorted coordination geometry of a complex from its typical arrangement that generates an improvement to its function. The entatic-state principle has been observed to apply to copper electron-transfer proteins and it results in a lowering of the reorganization energy of the electron-transfer process. It is thus crucial for a ...

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