Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures

Angewandte Chemie International Edition, 2014, DOI: 10.1002/anie.201409803, Volume 54, Issue 6, pages 1946–1949, published on 17.12.2014
Angewandte Chemie International Edition, online article
We report the development of dendritic siRNA nanostructures that are able to penetrate even difficult to transfect cells such as neurons with the help of a special receptor ligand. The nanoparticles elicit strong siRNA responses, despite the dendritic structure. An siRNA dendrimer directed against the crucial rabies virus (RABV) nucleoprotein (N protein) and phosphoprotein (P protein) allowed the suppression of the virus titer in neurons below the detection limit. The cell-penetrating siRNA dendrimers, which were assembled using click chemistry, open up new avenues toward finding novel molecules able to cure this deadly disease.  

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